The (Eigen)Value of Diffusion Tensor Imaging to Investigate Depression After Traumatic Brain Injury

Jerome J. Maller; Richard H. S. Thomson; Kerstin Pannek; Stephen E. Rose; Neil Bailey; Philip M. Lewis; Paul B. Fitzgerald

doi:10.1002/hbm.22171

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The (Eigen)Value of Diffusion Tensor Imaging to Investigate Depression After Traumatic Brain Injury

Journal article

Peer reviewed

The (Eigen)Value of Diffusion Tensor Imaging to Investigate Depression After Traumatic Brain Injury

Jerome J. Maller, Richard H. S. Thomson, Kerstin Pannek, Stephen E. Rose, Neil Bailey, Philip M. Lewis and Paul B. Fitzgerald

Human brain mapping, Vol.35(1), pp.227-237

01/2014

DOI: 10.1002/hbm.22171

PMCID: PMC6869024

PMID: 23008175

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https://www.ncbi.nlm.nih.gov/pmc/articles/6869024View

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Abstract

Background: Many people with a traumatic brain injury (TBI), even mild to moderate, will develop major depression (MD). Recent studies of patients with MD suggest reduced fractional anisotropy (FA) in dorsolateral prefrontal cortex (DLPFC), temporal lobe tracts, midline, and capsule regions. Some of these pathways have also been found to have reduced FA in patients with TBI. It is unknown whether the pathways implicated in MD after TBI are similar to those with MD without TBI. This study sought to investigate whether there were specific pathways unique to TBI patients who develop MD. Methods: A sample of TBI-MD subjects (N = 14), TBI-no-MD subjects (N = 12), MD-no-TBI (N = 26), and control subjects (no TBI or MD, N = 23), using a strict measurement protocol underwent psychiatric assessments and diffusion tensor brain Magnetic Resonance Imaging (MRI). Results: The findings of this study indicate that (1) TBI patients who develop MD have reduced axial diffusivity in DLPFC, corpus callosum (CC), and nucleus accumbens white matter tracts compared to TBI patients who do not develop MD and (2) MD patients without a history of TBI have reduced FA along the CC. We also found that more severe MD relates to altered radial diffusivity. Conclusions: These findings suggest that compromise to specific white matter pathways, including both axonal and myelination aspects, after a mild TBI underlie the susceptibility of these patients developing MD. Hum Brain Mapp 35:227-237, 2014. (c) 2012 Wiley Periodicals, Inc.

Life Sciences & Biomedicine

Neuroimaging

Neurosciences

Neurosciences & Neurology

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: The (Eigen)Value of Diffusion Tensor Imaging to Investigate Depression After Traumatic Brain Injury
Creators: Jerome J. Maller - Monash University
Richard H. S. Thomson - Monash University
Kerstin Pannek - The University of Queensland
Stephen E. Rose - The University of Queensland
Neil Bailey - Monash University
Philip M. Lewis - The Alfred Hospital
Paul B. Fitzgerald - Monash University
Resource Type: Journal article
Publication Details: Human brain mapping, Vol.35(1), pp.227-237
DOI: 10.1002/hbm.22171
PMID: 23008175
PMCID: PMC6869024
NLM abbreviation: Hum Brain Mapp
ISSN: 1065-9471
eISSN: 1097-0193
Publisher: Wiley
Number of pages: 11
Language: English
Date published: 01/2014
Academic Unit: Radiology
Record Identifier: 9984848502102771

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