The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

J Danesh; S Erqou; M Walker; S G Thompson; R Tipping; C Ford; S Pressel; G Walldius; I Jungner; A R Folsom; L E Chambless; M Knuiman; P H Whincup; S G Wannamethee; R W Morris; J Willeit; S Kiechl; P Santer; A Mayr; N Wald; S Ebrahim; D A Lawlor; J W G Yarnell; J Gallacher; E Casiglia; V Tikhonoff; P J Nietert; S E Sutherland; D L Bachman; J E Keil; M Cushman; B M Psaty; R P Tracy; A Tybjaerg-Hansen; B G Nordestgaard; R Frikke-Schmidt; S Giampaoli; L Palmieri; S Panico; D Vanuzzo; L Pilotto; L Simons; J McCallum; Y Friedlander; F G R Fowkes; A J Lee; F B Smith; J Taylor; J Guralnik; C Phillips; R Wallace; D Blazer; K T Khaw; J H Jansson; C Donfrancesco; V Salomaa; K Harald; P Jousilahti; E Vartiainen; M Woodward; R B D'Agostino; P A Wolf; R S Vasan; M J Pencina; E M Bladbjerg; T Jorgensen; L Moller; J Jespersen; R Dankner; A Chetrit; F Lubin; A Rosengren; L Wilhelmsen; G Lappas; H Eriksson; C Bjorkelund; P Cremer; D Nagel; R Tilvis; T Strandberg; B Rodriguez; L M Bouter; R J Heine; J M Dekker; G Nijpels; C D A Stehouwer; E Rimm; J Pai; S Sato; H Iso; A Kitamura; H Noda; U Goldbourt; J T Salonen; K Nyyssönen; T-P Tuomainen; D Deeg; J L Poppelaars; T Meade; J Cooper; B Hedblad; G Berglund; G Engstrom; A Döring; W Koenig; C Meisinger; W Mraz; L Kuller; R Selmer; A Tverdal; W Nystad; R Gillum; M Mussolino; S Hankinson; J Manson; B De Stavola; C Knottenbelt; J A Cooper; K A Bauer; R D Rosenberg; Y Naito; I Holme; H Nakagawa; H Miura; P Ducimetiere; X Jouven; C Crespo; M Garcia-Palmieri; P Amouyel; D Arveiler; A Evans; J Ferrieres; H Schulte; G Assmann; J Shepherd; C Packard; N Sattar; B Cantin; B Lamarche; J-P Després; G R Dagenais; E Barrett-Connor; D Wingard; R Bettencourt; V Gudnason; T Aspelund; G Sigurdsson; B Thorsson; M Trevisan; J Witteman; I Kardys; M Breteler; A Hofman; H Tunstall-Pedoe; R Tavendale; G D O Lowe; Y Ben-Shlomo; B V Howard; Y Zhang; L Best; J Umans; A Onat; T W Meade; I Njolstad; E Mathiesen; M L Lochen; T Wilsgaard; J M Gaziano; M Stampfer; P Ridker; H Ulmer; G Diem; H Concin; F Rodeghiero; A Tosetto; E Brunner; M Shipley; J Buring; S M Cobbe; I Ford; M Robertson; Y He; A M Ibanez; E J M Feskens; D Kromhout; R Collins; E Di Angelantonio; S Kaptoge; S Lewington; L Orfei; L Pennells; P Perry; K Ray; N Sarwar; M Scherman; A Thompson; S Watson; F Wensley; I R White; A M Wood; Emerging Risk Factors Collaboration

doi:10.1007/s10654-007-9165-7

Back

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

Journal article

Peer reviewed

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

J Danesh, S Erqou, M Walker, S G Thompson, R Tipping, C Ford, S Pressel, G Walldius, I Jungner, A R Folsom, …

European journal of epidemiology, Vol.22(12), pp.839-869

2007

DOI: 10.1007/s10654-007-9165-7

PMID: 17876711

Files and links (1)

url

https://research.wur.nl/en/publications/the-emerging-risk-factors-collaboration-analysis-of-individual-daView

Open Access

Abstract

Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid and inflammatory markers, other characteristics, as well as major cardiovascular morbidity and cause-specific mortality. Information on repeat measurements on relevant characteristics has been collected in approximately 340,000 participants to enable estimation of and correction for within-person variability. Re-analysis of individual data will yield up to approximately 69,000 incident fatal or nonfatal first ever major cardiovascular outcomes recorded during about 11.7 million person years at risk. The primary analyses will involve age-specific regression models in people without known baseline cardiovascular disease in relation to fatal or nonfatal first ever coronary heart disease outcomes. This initiative will characterize more precisely and in greater detail than has previously been possible the shape and strength of the age- and sex-specific associations of several lipid and inflammatory markers with incident coronary heart disease outcomes (and, secondarily, with other incident cardiovascular outcomes) under a wide range of circumstances. It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value.

Albumins - metabolism

Biomarkers - blood

Cardiovascular Diseases - blood

Cardiovascular Diseases - epidemiology

Cardiovascular Diseases - etiology

Databases, Factual

Far East - epidemiology

Humans

Inflammation - blood

Leukocyte Count

Lipids - blood

Lipoproteins, HDL - blood

Prospective Studies

Risk Factors

Triglycerides - blood

Details

Title: Subtitle: The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases
Creators: J Danesh
S Erqou
M Walker
S G Thompson
R Tipping
C Ford
S Pressel
G Walldius
I Jungner
A R Folsom
L E Chambless
M Knuiman
P H Whincup
S G Wannamethee
R W Morris
J Willeit
S Kiechl
P Santer
A Mayr
N Wald
S Ebrahim
D A Lawlor
J W G Yarnell
J Gallacher
E Casiglia
V Tikhonoff
P J Nietert
S E Sutherland
D L Bachman
J E Keil
M Cushman
B M Psaty
R P Tracy
A Tybjaerg-Hansen
B G Nordestgaard
R Frikke-Schmidt
S Giampaoli
L Palmieri
S Panico
D Vanuzzo
L Pilotto
L Simons
J McCallum
Y Friedlander
F G R Fowkes
A J Lee
F B Smith
J Taylor
J Guralnik
C Phillips
R Wallace
D Blazer
K T Khaw
J H Jansson
C Donfrancesco
V Salomaa
K Harald
P Jousilahti
E Vartiainen
M Woodward
R B D'Agostino
P A Wolf
R S Vasan
M J Pencina
E M Bladbjerg
T Jorgensen
L Moller
J Jespersen
R Dankner
A Chetrit
F Lubin
A Rosengren
L Wilhelmsen
G Lappas
H Eriksson
C Bjorkelund
P Cremer
D Nagel
R Tilvis
T Strandberg
B Rodriguez
L M Bouter
R J Heine
J M Dekker
G Nijpels
C D A Stehouwer
E Rimm
J Pai
S Sato
H Iso
A Kitamura
H Noda
U Goldbourt
J T Salonen
K Nyyssönen
T-P Tuomainen
D Deeg
J L Poppelaars
T Meade
J Cooper
B Hedblad
G Berglund
G Engstrom
A Döring
W Koenig
C Meisinger
W Mraz
L Kuller
R Selmer
A Tverdal
W Nystad
R Gillum
M Mussolino
S Hankinson
J Manson
B De Stavola
C Knottenbelt
J A Cooper
K A Bauer
R D Rosenberg
Y Naito
I Holme
H Nakagawa
H Miura
P Ducimetiere
X Jouven
C Crespo
M Garcia-Palmieri
P Amouyel
D Arveiler
A Evans
J Ferrieres
H Schulte
G Assmann
J Shepherd
C Packard
N Sattar
B Cantin
B Lamarche
J-P Després
G R Dagenais
E Barrett-Connor
D Wingard
R Bettencourt
V Gudnason
T Aspelund
G Sigurdsson
B Thorsson
M Trevisan
J Witteman
I Kardys
M Breteler
A Hofman
H Tunstall-Pedoe
R Tavendale
G D O Lowe
Y Ben-Shlomo
B V Howard
Y Zhang
L Best
J Umans
A Onat
T W Meade
I Njolstad
E Mathiesen
M L Lochen
T Wilsgaard
J M Gaziano
M Stampfer
P Ridker
H Ulmer
G Diem
H Concin
F Rodeghiero
A Tosetto
E Brunner
M Shipley
J Buring
S M Cobbe
I Ford
M Robertson
Y He
A M Ibanez
E J M Feskens
D Kromhout
R Collins
E Di Angelantonio
S Kaptoge
S Lewington
L Orfei
L Pennells
P Perry
K Ray
N Sarwar
M Scherman
A Thompson
S Watson
F Wensley
I R White
A M Wood
Emerging Risk Factors Collaboration
Resource Type: Journal article
Publication Details: European journal of epidemiology, Vol.22(12), pp.839-869
DOI: 10.1007/s10654-007-9165-7
PMID: 17876711
NLM abbreviation: Eur J Epidemiol
ISSN: 0393-2990
eISSN: 1573-7284
Grant note: MC_U137686853 / Medical Research Council MC_U105260792 / Medical Research Council G0401527 / Medical Research Council G0501792 / Medical Research Council G0600705 / Medical Research Council
Language: English
Date published: 2007
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984363624202771

Metrics

11 Record Views

120 Times Cited - Web of Science