The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions

Nohra Chalouhi; Pascal Jabbour; Vincent Magnotta; David Hasan

doi:10.3390/molecules18089670

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The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions

Journal article

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The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions

Nohra Chalouhi, Pascal Jabbour, Vincent Magnotta and David Hasan

Molecules (Basel, Switzerland), Vol.18(8), pp.9670-9683

08/2013

DOI: 10.3390/molecules18089670

PMCID: PMC6270297

PMID: 23945642

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Abstract

Inflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enhanced MRI has emerged as an important tool for noninvasive assessment of the inflammatory status of cerebrovascular lesions, namely aneurysms and arteriovenous malformations. Moreover, preliminary evidence suggests that ferumoxytol-enhanced MRI could be applied as a non-invasive tool to differentiate “unstable” lesions that require early intervention from “stable” lesions in which observation may be safe. Assessment of the effects of anti-inflammatory pharmacological interventions on cerebrovascular lesions is also a potentially crucial application of the technique. Future improvements in technique and MRI signal quantification will certainly pave the way for widespread and efficient use of ferumoxytol-enhanced MRI in clinical practice. In this paper, we review current data regarding ferumoxytol-enhanced MRI and discuss its current/potential applications and future perspectives.

arteriovenous malformation

aneurysm

magnetic resonance imaging

Review

ferumoxytol

inflammation

Details

Title: Subtitle: The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions
Creators: Nohra Chalouhi - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA; E-Mails
Pascal Jabbour - Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA; E-Mails
Vincent Magnotta - Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA; E-Mail
David Hasan - Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA; E-Mail
Resource Type: Journal article
Publication Details: Molecules (Basel, Switzerland), Vol.18(8), pp.9670-9683
DOI: 10.3390/molecules18089670
PMID: 23945642
PMCID: PMC6270297
NLM abbreviation: Molecules
ISSN: 1420-3049
eISSN: 1420-3049
Publisher: MDPI
Language: English
Date published: 08/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040273302771

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