The Epidermal Growth Factor Receptor and Its Ligands in Cardiovascular Disease

Nader Makki; Kristina W. Thiel; Francis J. Miller

doi:10.3390/ijms141020597

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The Epidermal Growth Factor Receptor and Its Ligands in Cardiovascular Disease

Journal article

Open access

Peer reviewed

The Epidermal Growth Factor Receptor and Its Ligands in Cardiovascular Disease

Nader Makki, Kristina W. Thiel and Francis J. Miller

International journal of molecular sciences, Vol.14(10), pp.20597-20613

10/15/2013

DOI: 10.3390/ijms141020597

PMCID: PMC3821633

PMID: 24132149

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Abstract

The epidermal growth factor receptor (EGFR) family and its ligands serve as a switchboard for the regulation of multiple cellular processes. While it is clear that EGFR activity is essential for normal cardiac development, its function in the vasculature and its role in cardiovascular disease are only beginning to be elucidated. In the blood vessel, endothelial cells and smooth muscle cells are both a source and a target of EGF-like ligands. Activation of EGFR has been implicated in blood pressure regulation, endothelial dysfunction, neointimal hyperplasia, atherogenesis, and cardiac remodeling. Furthermore, increased circulating EGF-like ligands may mediate accelerated vascular disease associated with chronic inflammation. Although EGFR inhibitors are currently being used clinically for the treatment of cancer, additional studies are necessary to determine whether abrogation of EGFR signaling is a potential strategy for the treatment of cardiovascular disease.

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

Details

Title: Subtitle: The Epidermal Growth Factor Receptor and Its Ligands in Cardiovascular Disease
Creators: Nader Makki - University of Iowa
Kristina W. Thiel - Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
Francis J. Miller - University of Iowa
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.14(10), pp.20597-20613
DOI: 10.3390/ijms141020597
PMID: 24132149
PMCID: PMC3821633
NLM abbreviation: Int J Mol Sci
ISSN: 1422-0067
eISSN: 1422-0067
Publisher: Mdpi
Number of pages: 17
Grant note: I01BX001729 / Veterans Affairs; US Department of Veterans Affairs GRNT12060205 / American Heart Association 1BX001729 / Office of Research and Development, Department of Veterans Affairs; US Department of Veterans Affairs
Language: English
Date published: 10/15/2013
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984383284202771

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