Journal article
The Essential Transcription Factor, Mcm1, Is a Downstream Target of Sln1, a Yeast "Two-component" Regulator
The Journal of biological chemistry, Vol.270(15), pp.8739-8743
04/14/1995
DOI: 10.1074/jbc.270.15.8739
PMID: 7721779
Abstract
In a search for mutants exhibiting altered activity of the yeast transcription factor, Mcm1, we have identified the SLN1 gene, whose product is highly related to bacterial two-component sensor-regulator proteins. sln1 alleles identified in our screen increased Mcm1p-mediated transcriptional activation, while deletion of the SLN1 locus severely reduced Mcm1p activity. Our data establish that Mcm1p is a downstream target of the Sln1 signaling pathway. Yeast Sln1p was recently shown to be involved in osmoregulation and to depend on the Hog1 MAP kinase (Maeda, T., Wurgler-Murphy, S., and Saito, H. (1994) Nature 369, 242-245). We show that SLN1-mediated regulation of Mcm1p activity is independent of the Hog1 MAP kinase, and suggest that the role of SLN1 is not restricted to osmoregulation.
Details
- Title: Subtitle
- The Essential Transcription Factor, Mcm1, Is a Downstream Target of Sln1, a Yeast "Two-component" Regulator
- Creators
- Guoying Yu - Genetics Ph.D. Program and Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242Robert J Deschenes - Biochemistry Department, University of Iowa, Iowa City, Iowa 52242Jan S Fassler - Genetics Ph.D. Program and Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.270(15), pp.8739-8743
- DOI
- 10.1074/jbc.270.15.8739
- PMID
- 7721779
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Publisher
- Elsevier Inc
- Grant note
- National Institutes of Health
- Language
- English
- Date published
- 04/14/1995
- Academic Unit
- Biology
- Record Identifier
- 9984217427802771
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