Journal article
The Evolution of Candida Species and Fluconazole Susceptibility among Oral and Vaginal Isolates Recovered from Human Immunodeficiency Virus (HIV)-Seropositive and At-Risk HIV-Seronegative Women
The Journal of infectious diseases, Vol.183(2), pp.286-293
01/15/2001
DOI: 10.1086/317936
PMID: 11204125
Abstract
Antifungal agents can effectively treat mucosal candidiasis; however, their use can lead to colonization with less susceptible species and to resistance among normally susceptible strains. Oral and vaginal Candida isolates obtained at 3 points over 2 years from human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women were identified by species and were evaluated for in vitro fluconazole susceptibility. Prevalence of non-C. albicans strains increased over time, and these strains were more likely among women reporting current antifungal use. Among C. albicans isolates, resistance was rare, with no evidence for progressive reduction in susceptibility over time. Among non-C. albicans isolates, reduced susceptibility occurred frequently and increased with time. HIV-seropositive women were more likely to have non-C. albicans isolates with reduced susceptibility as were women reporting current antifungal use. This evolution and selection of mucosa-colonizing Candida species with reduced susceptibility could play a critical early role in the development of antifungal resistance among C. albicans isolates responsible for refractory candidiasis.
Details
- Title: Subtitle
- The Evolution of Candida Species and Fluconazole Susceptibility among Oral and Vaginal Isolates Recovered from Human Immunodeficiency Virus (HIV)-Seropositive and At-Risk HIV-Seronegative Women
- Creators
- Jack D Sobel - Wayne State UniversitySuzanne E Ohmit - Wayne State UniversityPaula Schuman - Wayne State UniversityRobert S Klein - Albert Einstein College of MedicineKenneth Mayer - Brown UniversityAnn Duerr - Centers for Disease Control and PreventionJose A Vazquez - Wayne State UniversityAnne Rompalo - Johns Hopkins MedicineHIV Epidemiology Research Study (HERS) Group
- Contributors
- Denise Jamieson (Contributor) - University of Iowa, Obstetrics and Gynecology
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.183(2), pp.286-293
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/317936
- PMID
- 11204125
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 01/15/2001
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446060802771
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