Journal article
The Evolution of Insulin Administration in Type 1 Diabetes
Journal of diabetes mellitus, Vol.11(5), pp.249-277
2021
DOI: 10.4236/jdm.2021.115021
PMCID: PMC10516284
PMID: 37745178
Abstract
Insulin has been utilized in the treatment of type 1 diabetes (T1D) for 100 years. While there is still no cure for T1D, insulin administration has undergone a remarkable evolution which has contributed to improvements in quality of life and life expectancy in individuals with T1D. The advent of faster-acting and longer-acting insulins allowed for the implementation of insulin regimens more closely resembling normal insulin physiology. These improvements afforded better glycemic control, which is crucial for limiting microvascular complications and improving T1D outcomes. Suspension of insulin delivery in response to actual and forecasted hypoglycemia has improved quality of life and mitigated hypoglycemia without compromising glycemic control. Advances in continuous glucose monitoring (CGM) and insulin pumps, efforts to model glucose and insulin kinetics, and the application of control theory to T1D have made the automation of insulin delivery a reality. This review will summarize the past, present, and future of insulin administration in T1D.
Details
- Title: Subtitle
- The Evolution of Insulin Administration in Type 1 Diabetes
- Creators
- Catherina T. PinnaroMichael J. Tansey
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes mellitus, Vol.11(5), pp.249-277
- DOI
- 10.4236/jdm.2021.115021
- PMID
- 37745178
- PMCID
- PMC10516284
- NLM abbreviation
- J Diabetes Mellitus
- ISSN
- 2160-5831
- eISSN
- 2160-5858
- Language
- English
- Date published
- 2021
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984354509702771
Metrics
11 Record Views