The Evolving Biology of Microglia in Alzheimer's Disease

Tarja M. Malm; Taylor R. Jay; Gary E. Landreth

doi:10.1007/s13311-014-0316-8

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The Evolving Biology of Microglia in Alzheimer's Disease

Journal article

Open access

Peer reviewed

The Evolving Biology of Microglia in Alzheimer's Disease

Tarja M. Malm, Taylor R. Jay and Gary E. Landreth

Neurotherapeutics, Vol.12(1), pp.81-93

01/01/2015

DOI: 10.1007/s13311-014-0316-8

PMCID: PMC4322081

PMID: 25404051

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Abstract

Alzheimer's disease (AD) is typified by a robust microglial-mediated inflammatory response within the brain. Indeed, microglial accumulation around plaques in AD is one of the classical hallmarks of the disease pathology. Although microglia have the capacity to remove beta-amyloid deposits and alleviate disease pathology, they fail to do so. Instead, they become chronically activated and promote inflammation-mediated impairment of cognition and cytotoxicity. However, if microglial function could be altered to engage their phagocytic response, promote their tissue maintenance functions, and prevent release of factors that promote tissue damage, this could provide therapeutic benefit. This review is focused on the current knowledge of microglial homeostatic mechanisms in AD, and mechanisms involved in the regulation of microglial phenotype in this context.

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Pharmacology & Pharmacy

Science & Technology

Details

Title: Subtitle: The Evolving Biology of Microglia in Alzheimer's Disease
Creators: Tarja M. Malm - Finland University
Taylor R. Jay - Case Western Reserve University
Gary E. Landreth - Case Western Reserve University
Resource Type: Journal article
Publication Details: Neurotherapeutics, Vol.12(1), pp.81-93
DOI: 10.1007/s13311-014-0316-8
PMID: 25404051
PMCID: PMC4322081
NLM abbreviation: Neurotherapeutics
ISSN: 1933-7213
eISSN: 1878-7479
Publisher: Springer Nature
Number of pages: 13
Grant note: R56 NS084856 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) RF1 AG050597; RF1 AG051495 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
Language: English
Date published: 01/01/2015
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9985112881302771

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