Journal article
The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD
BioMed research international, Vol.2016, pp.1-17
2016
DOI: 10.1155/2016/2891810
PMCID: PMC5021463
PMID: 27656649
Abstract
Airway smooth muscle (ASM) remodeling is a hallmark in chronic obstructive pulmonary disease (COPD), and nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases (NOXs) produced reactive oxygen species (ROS) play a crucial role in COPD pathogenesis. In the present study, the expression of NOX4 and its correlation with the ASM hypertrophy/hyperplasia, clinical pulmonary functions, and the expression of transforming growth factor
β
(TGF-
β
) in the ASM of COPD small airways were investigated by semiquantitative morphological and/or immunohistochemistry staining methods. The results showed that an elevated expression of NOX4 and TGF-
β
, along with an increased volume of ASM mass, was found in the ASM of small airways in COPD patients. The abundance of NOX4 protein in the ASM was increased with disease severity and inversely correlated with the pulmonary functions in COPD patients. In addition, the expression of NOX4 and ASM marker
α
-SMA was colocalized, and the increased NOX4 expression was found to accompany an upregulated expression of TGF-
β
in the ASM of small airways of COPD lung. These results indicate that NOX4 may be a key regulator in ASM remodeling of small airway, in part through a mechanism interacting with TGF-
β
signaling in the pathogenesis of COPD, which warrants further investigation.
Details
- Title: Subtitle
- The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD
- Creators
- Xianyan Liu - Ningxia Medical UniversityBinwei Hao - Ningxia Medical UniversityAiling Ma - Ningxia Medical UniversityJinxi He - Ningxia Medical UniversityXiaoming Liu - Ningxia Medical UniversityJuan Chen - Ningxia Medical University
- Resource Type
- Journal article
- Publication Details
- BioMed research international, Vol.2016, pp.1-17
- DOI
- 10.1155/2016/2891810
- PMID
- 27656649
- PMCID
- PMC5021463
- NLM abbreviation
- Biomed Res Int
- ISSN
- 2314-6133
- eISSN
- 2314-6141
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81360004
- Language
- English
- Date published
- 2016
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984288756902771
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