Journal article
The FDG lumped constant in normal human brain
The Journal of nuclear medicine (1978), Vol.43(9), pp.1157-1166
2002
PMID: 12215553
Abstract
Abstract
The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MR(glc)) from FDG metabolic rate (MR(FDG)).
Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MR(glc) and MR(FDG) independently using 1-(11)C-glucose and (18)F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models.
Results: The mean LC (+/-SD) for normal brain was found to be 0.89 +/- 0.08. The value for cerebellum was slightly lower, 0.78 +/- 0.11 (P = 0.006; 2-tailed paired t test).
Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.
Details
- Title: Subtitle
- The FDG lumped constant in normal human brain
- Creators
- Michael M GRAHAM - Division of Nuclear Medicine, Department of Radiology, University of Iowa, Iowa City, Iowa, United StatesMark MUZI - Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington, United StatesAlexander M SPENCE - Department of Neurology, University of Washington, Seattle, Washington, United StatesFinbarr O'SULLIVAN - Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington, United StatesThomas K LEWELLEN - Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington, United StatesJeanne M LINK - Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington, United StatesKenneth A KROHN - Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.43(9), pp.1157-1166
- Publisher
- Society of Nuclear Medicine; Reston, VA
- PMID
- 12215553
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 2002
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984046825002771
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