Journal article
The FaceBase Consortium: A comprehensive program to facilitate craniofacial research
Developmental biology, Vol.355(2), pp.175-182
07/15/2011
DOI: 10.1016/j.ydbio.2011.02.033
PMCID: PMC3440302
PMID: 21458441
Abstract
The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.
► FaceBase will create comprehensive gene expression, regulatory element and sequencing datasets. ► FaceBase will generate anatomical and molecular atlases. ► FaceBase will provide human normative facial data and other phenotypes. ► FaceBase will build repositories of animal models and human samples and data for analysis. ► FaceBase will serve as a community forum for researchers, clinicians and educator outreach.
Details
- Title: Subtitle
- The FaceBase Consortium: A comprehensive program to facilitate craniofacial research
- Creators
- Harry Hochheiser - Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh PA 15232, USABruce J Aronow - Division of Biomedical Informatics, Center for Computational Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, CHRF 8504, 3333 Burnet Ave Cincinnati, OH 45229, USAKristin Artinger - Department of Craniofacial Biology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USATerri H Beaty - Department of Epidemiology, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USAJames F Brinkley - Department of Computer Science and Engineering, University of Washington, Box 352350 Seattle, WA 98195-2350, USAYang Chai - Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USADavid Clouthier - Department of Craniofacial Biology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USAMichael L Cunningham - Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USAMichael Dixon - Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Center, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UKLeah Rae Donahue - Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609, USAScott E Fraser - Biological Imaging Center Beckman Institute 133, M/C 139-74 California Institute of Technology Pasadena, CA 91125, USABenedikt Hallgrimsson - Dept. of Cell Biology and Anatomy and the Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, CanadaJunichi Iwata - Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USAOphir Klein - Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, USAMary L Marazita - Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USAJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USAStephen Murray - Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609, USAFernando Pardo-Manuel de Villena - Department of Genetics The University of North Carolina at Chapel Hill120 Mason Farm Road Room 5046 Genetic Medicine Building Campus Box 7264, Chapel Hill, NC 27599-7264, USAJohn Postlethwait - Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USASteven Potter - Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USALinda Shapiro - Department of Computer Science and Engineering, University of Washington, Box 352350 Seattle, WA 98195-2350, USARichard Spritz - Human Medical Genetics Program, University of Colorado School of Medicine, Aurora, CO 80045, USAAxel Visel - Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USASeth M Weinberg - Center for Craniofacial and Dental Genetics Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Bridgeside Point Building 100 Technology Drive, Suite 500 Pittsburgh, PA 15219, USAPaul A Trainor - Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
- Resource Type
- Journal article
- Publication Details
- Developmental biology, Vol.355(2), pp.175-182
- DOI
- 10.1016/j.ydbio.2011.02.033
- PMID
- 21458441
- PMCID
- PMC3440302
- NLM abbreviation
- Dev Biol
- ISSN
- 0012-1606
- eISSN
- 1095-564X
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000072, name: NIDCR, award: U01-DE20049, U01-DE20050, U01-DE20052, U01-DE20054, U01-DE020057, U01-DE20060, U01-DE20063, U01-DE20065, U01-DE20073, U01-DE20076, U01-DE20078
- Language
- English
- Date published
- 07/15/2011
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025453702771
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