Journal article
The Frequency of Human Papillomavirus Detection in Postmenopausal Women on Hormone Replacement Therapy
Gynecologic oncology, Vol.65(3), pp.441-446
06/1997
DOI: 10.1006/gyno.1997.4703
PMID: 9190973
Abstract
Postmenopausal women enrolled in the Iowa portion of the postmenopausal estrogen/progestin interventions randomized clinical trial (n= 105) during 1989–1991 were studied for (i) the prevalence of human papillomavirus (HPV) in this older age population (ages 45–64), and (ii) the association between hormone replacement therapies (HRTs) and changes in detection of HPV over a 2-year time period. HPV is causative in most cervical and some other genital cancers and in the presence of steroid hormones has been shown to increase neoplastic transformation by HPVin vitro.Using PCR to detect HPV DNA, the overall frequency of the virus regardless of time period was 50.3% (n= 53) with a baseline (BL) frequency of 38.1% and the second year follow-up (FU) of 22.9%. The oncogenic types HPV-16 (75.5%) and HPV-31 (20.8%) were the most commonly reported. All those with persistently detected infection (10.5%), defined as HPV+ at both BL and FU, were identified with HPV-16 or -18. Between these two time periods there were no significant differences in HPV frequency between the placebo and combined HRT groups (BL−/FU+, 21% vs 18%; BL+/FU−, 71% vs 80%). While the study is based on a small sample, the findings suggest that short-term use of HRTs is not associated with an increased risk of HPV detection, but assessment of effects from long-term use is needed. The data also indicate that the frequency of HPV found in older women is higher than previously suspected but that short-term changes in HPV detected in this age group are unrelated to the development of precancerous cervical lesions.
Details
- Title: Subtitle
- The Frequency of Human Papillomavirus Detection in Postmenopausal Women on Hormone Replacement Therapy
- Creators
- E.M Smith - Department of Preventive Medicine, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242S.R Johnson - Department of Obstetrics/Gynecology, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242E.J Figuerres - Department of Preventive Medicine, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242M Mendoza - Department of Preventive Medicine, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242D Fedderson - Department of Obstetrics/Gynecology, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242T.H Haugen - Department of Pathology, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242L.P Turek - Department of Pathology, Veterans Administration Medical Center and University of Iowa, College of Medicine, Iowa City, Iowa, 52242
- Resource Type
- Journal article
- Publication Details
- Gynecologic oncology, Vol.65(3), pp.441-446
- Publisher
- Elsevier Inc
- DOI
- 10.1006/gyno.1997.4703
- PMID
- 9190973
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Language
- English
- Date published
- 06/1997
- Academic Unit
- Epidemiology; Pathology; Obstetrics and Gynecology
- Record Identifier
- 9984047633302771
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