The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

Jack T Stapleton; Steven Foung; A. Scott Muerhoff; Jens Bukh; Peter Simmonds

doi:10.1099/vir.0.027490-0

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The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

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The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

Jack T Stapleton, Steven Foung, A. Scott Muerhoff, Jens Bukh and Peter Simmonds

Journal of general virology, Vol.92(Pt 2), pp.233-246

02/2011

DOI: 10.1099/vir.0.027490-0

PMCID: PMC3081076

PMID: 21084497

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Abstract

In 1967, it was reported that experimental inoculation of serum from a surgeon (G.B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae , named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the 11th GB passage. Neither virus infects humans, and a number of GBV-A variants were identified in wild New World monkeys that were captured. Subsequently, a related human virus was identified [named GBV-C or hepatitis G virus (HGV)], and recently a more distantly related virus (named GBV-D) was discovered in bats. Only GBV-B, a second species within the genus Hepacivirus (type species hepatitis C virus), has been shown to cause hepatitis; it causes acute hepatitis in experimentally infected tamarins. The other GB viruses have however not been assigned to a genus within the family Flaviviridae . Based on phylogenetic relationships, genome organization and pathogenic features of the GB viruses, we propose to classify GBV-A-like viruses, GBV-C and GBV-D as members of a fourth genus in the family Flaviviridae , named Pegivirus (pe, persistent; g, GB or G). We also propose renaming ‘GB’ viruses within the tentative genus Pegivirus to reflect their host origin.

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Title: Subtitle: The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
Creators: Jack T Stapleton - Department of Internal Medicine, Veterans Administration Medical Center and the University of Iowa, Iowa City, IA, USA
Steven Foung - Department of Pathology, Stanford University, Stanford, CA, USA
A. Scott Muerhoff - Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL, USA
Jens Bukh - Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, and Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Denmark
Peter Simmonds - Centre for Infectious Diseases, University of Edinburgh, Edinburgh, UK
Resource Type: Journal article
Publication Details: Journal of general virology, Vol.92(Pt 2), pp.233-246
DOI: 10.1099/vir.0.027490-0
PMID: 21084497
PMCID: PMC3081076
NLM abbreviation: J Gen Virol
ISSN: 0022-1317
eISSN: 1465-2099
Publisher: Society for General Microbiology
Language: English
Date published: 02/2011
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094355202771

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