Journal article
The GBV-C envelope glycoprotein E2 does not interact specifically with CD81
AIDS (London), Vol.21(8), pp.1045-1048
2007
DOI: 10.1097/QAD.0b013e3280f77412
PMID: 17457101
Abstract
The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81 is the GBV-C E2 cellular receptor. We found that E2 binding to cells was not dependent upon human CD81, and that soluble CD81 did not compete with GBV-C E2 for cell binding. GBV-C E2 protein thus does not appear to interact with CD81.
Details
- Title: Subtitle
- The GBV-C envelope glycoprotein E2 does not interact specifically with CD81
- Creators
- Thomas M KAUFMAN - Lowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United StatesJames H MCLINDEN - Lowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United StatesJINHUA XIANG - Lowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United StatesAlfred M ENGEL - Roche Diagnostics GmbH, Penzberg, GermanyJack T STAPLETON - Lowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.21(8), pp.1045-1048
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/QAD.0b013e3280f77412
- PMID
- 17457101
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Language
- English
- Date published
- 2007
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094384302771
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