Journal article
The Gut Microbiome Modulates Body Temperature Both in Sepsis and Health
American journal of respiratory and critical care medicine, Vol.207(8), pp.1030-1041
04/15/2023
DOI: 10.1164/rccm.202201-0161OC
PMCID: PMC10112447
PMID: 36378114
Abstract
Among patients with sepsis, variation in temperature trajectories predicts clinical outcomes. In healthy individuals, normal body temperature is variable and has decreased consistently since the 1860s. The biologic underpinnings of this temperature variation in disease and health are unknown.
To establish and interrogate the role of the gut microbiome in calibrating body temperature.
We performed a series of translational analyses and experiments to determine whether and how variation in gut microbiota explains variation in body temperature in sepsis and in health. We studied patient temperature trajectories using electronic medical record data. We characterized gut microbiota in hospitalized patients using 16S ribosomal RNA gene sequencing. We modeled sepsis using intraperitoneal LPS in mice and modulated the microbiome using antibiotics, germ-free, and gnotobiotic animals.
Consistent with prior work, we identified four temperature trajectories in patients hospitalized with sepsis that predicted clinical outcomes. In a separate cohort of 116 hospitalized patients, we found that the composition of patients' gut microbiota at admission predicted their temperature trajectories. Compared with conventional mice, germ-free mice had reduced temperature loss during experimental sepsis. Among conventional mice, heterogeneity of temperature response in sepsis was strongly explained by variation in gut microbiota. Healthy germ-free and antibiotic-treated mice both had lower basal body temperatures compared with control animals. The
family was consistently associated with temperature trajectories in hospitalized patients, experimental sepsis, and antibiotic-treated mice.
The gut microbiome is a key modulator of body temperature variation in both health and critical illness and is thus a major, understudied target for modulating physiologic heterogeneity in sepsis.
Details
- Title: Subtitle
- The Gut Microbiome Modulates Body Temperature Both in Sepsis and Health
- Creators
- Kale S Bongers - University of Michigan–Ann ArborRishi Chanderraj - University of Michigan–Ann ArborRobert J Woods - VA Ann Arbor Healthcare SystemRoderick A McDonald - University of Michigan–Ann ArborMark D Adame - University of Michigan–Ann ArborNicole R Falkowski - University of Michigan–Ann ArborChristopher A Brown - University of Michigan–Ann ArborJennifer M Baker - University of Michigan–Ann ArborKatherine M Winner - University of Michigan–Ann ArborDaniel J Fergle - University of Michigan–Ann ArborKevin J Hinkle - University of Michigan–Ann ArborAlexandra K Standke - University of Michigan–Ann ArborKimberly C Vendrov - University of Michigan–Ann ArborVincent B Young - University of Michigan–Ann ArborKathleen A Stringer - Ann Arbor Center for Independent LivingMichael W Sjoding - University of Michigan–Ann ArborRobert P Dickson - University of Michigan–Ann Arbor
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.207(8), pp.1030-1041
- Publisher
- American Thoracic Society
- DOI
- 10.1164/rccm.202201-0161OC
- PMID
- 36378114
- PMCID
- PMC10112447
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Grant note
- T32 GM007863 / NIGMS NIH HHS R01 LM013325 / NLM NIH HHS F31 HL158033 / NHLBI NIH HHS U19 AI090871 / NIAID NIH HHS R01 HL144599 / NHLBI NIH HHS R35 GM136312 / NIGMS NIH HHS R01 HL158626 / NHLBI NIH HHS K24 HL159247 / NHLBI NIH HHS T32 HL007749 / NHLBI NIH HHS U01 AI124255 / NIAID NIH HHS T32 AI007528 / NIAID NIH HHS K01 HL136687 / NHLBI NIH HHS R01 AI143852 / NIAID NIH HHS
- Language
- English
- Date published
- 04/15/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984696753202771
Metrics
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