The Heterochromatin Protein 1 family

Gwen Lomberk; Lori Wallrath; Raul Urrutia

doi:10.1186/gb-2006-7-7-228

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Journal article

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The Heterochromatin Protein 1 family

Gwen Lomberk, Lori Wallrath and Raul Urrutia

Genome biology, Vol.7(7), pp.228-228

2006

DOI: 10.1186/gb-2006-7-7-228

PMCID: PMC1779566

PMID: 17224041

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Abstract

Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species. The amino-terminal chromodomain binds methylated lysine 9 of histone H3, causing transcriptional repression. The highly conserved carboxy-terminal chromoshadow domain enables dimerization and also serves as a docking site for proteins involved in a wide variety of nuclear functions, from transcription to nuclear architecture. In addition to heterochromatin packaging, it is becoming increasingly clear that HP1 proteins have diverse roles in the nucleus, including the regulation of euchromatic genes. HP1 proteins are amenable to posttranslational modifications that probably regulate these distinct functions, thereby creating a subcode within the context of the 'histone code' of histone posttranslational modifications.

Animals

Chromosomal Proteins, Non-Histone - metabolism

Drosophila

Humans

Chromosomal Proteins, Non-Histone - physiology

Protein Processing, Post-Translational

Phylogeny

Chromosomal Proteins, Non-Histone - genetics

Evolution, Molecular

Details

Title: Subtitle: The Heterochromatin Protein 1 family
Creators: Gwen Lomberk - Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic, Rochester, MN 55905, USA
Lori Wallrath
Raul Urrutia
Resource Type: Journal article
Publication Details: Genome biology, Vol.7(7), pp.228-228
Publisher: England
DOI: 10.1186/gb-2006-7-7-228
PMID: 17224041
PMCID: PMC1779566
ISSN: 1474-760X
eISSN: 1474-760X
Grant note: DK52913 / NIDDK NIH HHS R56 DK052913 / NIDDK NIH HHS GM61513 / NIGMS NIH HHS R01 DK052913-09 / NIDDK NIH HHS R01 DK056620 / NIDDK NIH HHS R01 GM061513 / NIGMS NIH HHS DK56620 / NIDDK NIH HHS R01 DK052913 / NIDDK NIH HHS
Language: English
Date published: 2006
Academic Unit: Biochemistry and Molecular Biology; University College Courses
Record Identifier: 9984024562002771

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