The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study

Maryam Vasaghi Gharamaleki; Maryam Habibagahi; Etrat Hooshmandi; Reza Tabrizi; Shahram Arsang-Jang; Zohreh Barzegar; Nima Fadakar; Vahid Reza Ostovan; Abbas Rahimi-Jaberi; Nahid Ashjazadeh; Peyman Petramfar; Maryam Poursadeghfard; Sadegh Izadi; Masoumeh Nazeri; Hanieh Bazrafshan; Zahra Bahrami; Sedigheh Karimlu; Seyedeh Shaghayegh Zafarmand; Mahnaz Bayat; Mohammad Saied Salehi; Maryam Owjfard; Saeideh Karimi-Haghighi; Anahid Safari; Banafsheh Shakibajahromi; Beng Lim Alvin Chew; Bradford B. g Worral; Jonathan M. Coutinho; Carlos Garcia-Esperon; Neil Spratt; Christopher Levi; Mahmoud Reza Azarpazhooh; Afshin Borhani-Haghighi

doi:10.1016/j.jstrokecerebrovasdis.2022.106468

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The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study

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The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study

Maryam Vasaghi Gharamaleki, Maryam Habibagahi, Etrat Hooshmandi, Reza Tabrizi, Shahram Arsang-Jang, Zohreh Barzegar, Nima Fadakar, Vahid Reza Ostovan, Abbas Rahimi-Jaberi, Nahid Ashjazadeh, …

Journal of stroke and cerebrovascular diseases, Vol.31(7), pp.106468-106468

07/01/2022

DOI: 10.1016/j.jstrokecerebrovasdis.2022.106468

PMCID: PMC8947940

PMID: 35523051

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https://pure.amsterdamumc.nl/en/publications/c0d8e98e-7443-4374-b918-cc8b325cbe2fView

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Abstract

There are several reports of the association between SARS-CoV-2 infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. 50 and 77 adult CVST patients were hospitalized in the pre-COVID-19 and COVID-19 periods, respectively. The crude CVST hospitalization rate increased from 14.33 in the pre-COVID-19 period to 21.7 per million in the COVID-19 era (P = 0.021). However, after age and sex adjustment, the incremental trend in hospitalization rate was not significant (95% CrI: -2.2, 5.14). Patients > 50-year-old were more often hospitalized in the COVID-19 period (P = 0.042). SARS-CoV-2 PCR test was done in 49.3% out of all COVID-19 period patients, which were positive in 6.5%. Modified Rankin Scale (mRS) score ≥3 at three-month follow-up was associated with age (P = 0.015) and malignancy (P = 0.014) in pre-COVID period; and was associated with age (P = 0.025), altered mental status on admission time (P<0.001), malignancy (P = 0.041) and COVID-19 infection (P = 0.008) in COVID-19 period. Since there was a more dismal outcome in COVID-19 associated CVST, a high index of suspicion for CVST among COVID-19 positive is recommended.

Stroke

COVID-19

Hospitalization rate

Prognosis

SARS-CoV-2

Sinus thrombosis

Details

Title: Subtitle: The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study
Creators: Maryam Vasaghi Gharamaleki - Shiraz University of Medical Sciences
Maryam Habibagahi - Shiraz University of Medical Sciences
Etrat Hooshmandi - Shiraz University of Medical Sciences
Reza Tabrizi - Fasa University of Medical Sciences
Shahram Arsang-Jang - Zanjan University of Medical Sciences
Zohreh Barzegar - Shiraz University of Medical Sciences
Nima Fadakar - Shiraz University of Medical Sciences
Vahid Reza Ostovan - Shiraz University of Medical Sciences
Abbas Rahimi-Jaberi - Shiraz University of Medical Sciences
Nahid Ashjazadeh - Shiraz University of Medical Sciences
Peyman Petramfar - Shiraz University of Medical Sciences
Maryam Poursadeghfard - Shiraz University of Medical Sciences
Sadegh Izadi - Shiraz University of Medical Sciences
Masoumeh Nazeri - Shiraz University of Medical Sciences
Hanieh Bazrafshan - Shiraz University of Medical Sciences
Zahra Bahrami - Shiraz University of Medical Sciences
Sedigheh Karimlu - Shiraz University of Medical Sciences
Seyedeh Shaghayegh Zafarmand - Shiraz University of Medical Sciences
Mahnaz Bayat - Shiraz University of Medical Sciences
Mohammad Saied Salehi - Shiraz University of Medical Sciences
Maryam Owjfard - Shiraz University of Medical Sciences
Saeideh Karimi-Haghighi - Shiraz University of Medical Sciences
Anahid Safari - Shiraz University of Medical Sciences
Banafsheh Shakibajahromi - Shiraz University of Medical Sciences
Beng Lim Alvin Chew - John Hunter Hospital
Bradford B. g Worral - University of Virginia
Jonathan M. Coutinho - Amsterdam University Medical Centers
Carlos Garcia-Esperon - Hunter Medical Research Institute
Neil Spratt - Hunter Medical Research Institute
Christopher Levi - John Hunter Hospital
Mahmoud Reza Azarpazhooh - Western University
Afshin Borhani-Haghighi - Shiraz University of Medical Sciences
Resource Type: Journal article
Publication Details: Journal of stroke and cerebrovascular diseases, Vol.31(7), pp.106468-106468
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106468
PMID: 35523051
PMCID: PMC8947940
NLM abbreviation: J Stroke Cerebrovasc Dis
ISSN: 1052-3057
eISSN: 1532-8511
Publisher: Elsevier Inc
Language: English
Date published: 07/01/2022
Academic Unit: Neurology
Record Identifier: 9985013727402771

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