Journal article
The Host Cellular Immune Response to Infection by Campylobacter Spp. and Its Role in Disease
Infection and immunity, Vol.89(8), pp.e0011621-e0011621
07/15/2021
DOI: 10.1128/IAI.00116-21
PMCID: PMC8281273
PMID: 34031129
Abstract
Campylobacter
spp. are the leading cause of bacterium-derived gastroenteritis worldwide, impacting 96 million individuals annually. Unlike other bacterial pathogens of the gastrointestinal tract,
Campylobacter
spp. lack many of the classical virulence factors that are often associated with the ability to induce disease in humans, including an array of canonical secretion systems and toxins.
ABSTRACT
Campylobacter
spp. are the leading cause of bacterium-derived gastroenteritis worldwide, impacting 96 million individuals annually. Unlike other bacterial pathogens of the gastrointestinal tract,
Campylobacter
spp. lack many of the classical virulence factors that are often associated with the ability to induce disease in humans, including an array of canonical secretion systems and toxins. Consequently, the clinical manifestations of human campylobacteriosis and its resulting gastrointestinal pathology are believed to be primarily due to the host immune response toward the bacterium. Further, while gastrointestinal infection is usually self-limiting, numerous postinfectious disorders can occur, including the development of Guillain-Barré syndrome, reactive arthritis, and irritable bowel syndrome. Because gastrointestinal disease likely results from the host immune response, the development of these postinfectious disorders may be due to dysregulation or misdirection of the same inflammatory response. As a result, it is becoming increasingly important to the
Campylobacter
field, and human health, that the cellular immune responses toward
Campylobacter
be better understood, including which immunological events are critical to the development of disease and the postinfectious disorders mentioned above. In this review, we collectively cover the cellular immune responses across susceptible hosts to
Campylobacter jejuni
infection, along with the tissue pathology and postinfectious disorders which may develop.
Details
- Title: Subtitle
- The Host Cellular Immune Response to Infection by Campylobacter Spp. and Its Role in Disease
- Creators
- Sean M. Callahan - University of Tennessee at KnoxvilleCarolina G. Dolislager - University of Tennessee at KnoxvilleJeremiah G. Johnson - University of Tennessee at Knoxville
- Contributors
- Karen M. Ottemann (Editor)
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.89(8), pp.e0011621-e0011621
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/IAI.00116-21
- PMID
- 34031129
- PMCID
- PMC8281273
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Language
- English
- Date published
- 07/15/2021
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696582202771
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