The Human Microbiome and Surgical Disease

Michael J MOROWITZ; Trissa BABROWSKI; Erica M CARLISLE; Andrea OLIVAS; Kathleen S ROMANOWSKI; John B SEAL; Donald C LIU; John C ALVERDY

doi:10.1097/SLA.0b013e31821175d7

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The Human Microbiome and Surgical Disease

Journal article

Peer reviewed

The Human Microbiome and Surgical Disease

Michael J MOROWITZ, Trissa BABROWSKI, Erica M CARLISLE, Andrea OLIVAS, Kathleen S ROMANOWSKI, John B SEAL, Donald C LIU and John C ALVERDY

Annals of surgery, Vol.253(6), pp.1094-1101

2011

DOI: 10.1097/SLA.0b013e31821175d7

PMCID: PMC4854204

PMID: 21422915

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Abstract

Objective: The purpose of this review article is to summarize what is currently known about microbes associated with the human body and to provide examples of how this knowledge impacts the care of surgical patients. Background: Pioneering research over the past decade has demonstrated that human beings live in close, constant contact with dynamic communities of microbial organisms. This new reality has wide-ranging implications for the care of surgical patients. Methods and results: Recent advances in the culture-independent study of the human microbiome are reviewed. To illustrate the translational relevance of these studies to surgical disease, we discuss in detail what is known about the role of microbes in the pathogenesis of obesity, gastrointestinal malignancies, Crohn disease, and perioperative complications including surgical site infections and sepsis. The topics of mechanical bowel preparation and perioperative antibiotics are also discussed. Conclusions: Heightened understanding of the microbiome in coming years will likely offer opportunities to refine the prevention and treatment of a wide variety of surgical conditions.

Biological and medical sciences

General aspects

Medical sciences

Details

Title: Subtitle: The Human Microbiome and Surgical Disease
Creators: Michael J MOROWITZ - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
Trissa BABROWSKI - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
Erica M CARLISLE - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
Andrea OLIVAS - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
Kathleen S ROMANOWSKI - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
John B SEAL - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
Donald C LIU - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
John C ALVERDY - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
Resource Type: Journal article
Publication Details: Annals of surgery, Vol.253(6), pp.1094-1101
DOI: 10.1097/SLA.0b013e31821175d7
PMID: 21422915
PMCID: PMC4854204
NLM abbreviation: Ann Surg
ISSN: 0003-4932
eISSN: 1528-1140
Publisher: Ovid Technologies (Wolters Kluwer Health); Hagerstown, MD
Language: English
Date published: 2011
Academic Unit: Stead Family Department of Pediatrics; Surgery
Record Identifier: 9984051727802771

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