Journal article
The Immediate Early Genes of Human Cytomegalovirus Upregulate Expression of the Interleukin-2 and Interleukin-2 Receptor Genes
American journal of respiratory cell and molecular biology, Vol.5(3), pp.292-296
09/1991
DOI: 10.1165/ajrcmb/5.3.292
PMID: 1654952
Abstract
Human cytomegalovirus (HCMV) immediate early (IE) genes act as trans-acting factors to upregulate various viral promoters. We used various IE plasmid constructs in transient transfection assays and demonstrated that the HCMV IE2 gene product upregulated expression from the interleukin (IL)-2 and IL-2 receptor (IL-2R) promoters and increased amounts of endogenous, steady-state IL-2 and IL-2R RNA. In marked contrast, the IE1 gene product, which can upregulate the major IE promoter and the IL-1β promoter, had no effect on the IL-2 and IL-2R promoters. These studies suggest a role for the HCMV IE2 gene product as a modulator of the inflammatory response associated with HCMV infection.
Details
- Title: Subtitle
- The Immediate Early Genes of Human Cytomegalovirus Upregulate Expression of the Interleukin-2 and Interleukin-2 Receptor Genes
- Creators
- Lois J GeistMartha M MonickMark F StinskiGary W Hunninghake
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory cell and molecular biology, Vol.5(3), pp.292-296
- DOI
- 10.1165/ajrcmb/5.3.292
- PMID
- 1654952
- ISSN
- 1044-1549
- eISSN
- 1535-4989
- Language
- English
- Date published
- 09/1991
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Microbiology and Immunology; Provost Office Administration; Internal Medicine
- Record Identifier
- 9984213293702771
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