Journal article
The Immune Landscape of Cancer
Immunity (Cambridge, Mass.), Vol.48(4), pp.812-830.e14
04/17/2018
DOI: 10.1016/j.immuni.2018.03.023
PMCID: PMC5982584
PMID: 29628290
Abstract
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferation, expression of immunomodulatory genes, and prognosis. Specific driver mutations correlated with lower (CTNNB1, NRAS, or IDH1) or higher (BRAF, TP53, or CASP8) leukocyte levels across all cancers. Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes. Our immunogenomics pipeline to characterize these heterogeneous tumors and the resulting data are intended to serve as a resource for future targeted studies to further advance the field.
Details
- Title: Subtitle
- The Immune Landscape of Cancer
- Creators
- Vésteinn Thorsson - Institute for Systems BiologyDavid L Gibbs - Institute for Systems BiologyScott D Brown - BC Cancer AgencyDenise Wolf - University of California, San FranciscoDante S Bortone - University of North Carolina at Chapel HillTai-Hsien Ou Yang - Columbia UniversityEduard Porta-Pardo - Barcelona Supercomputing CenterGalen F Gao - Massachusetts Institute of TechnologyChristopher L Plaisier - Arizona State UniversityJames A Eddy - Sage BionetworksElad Ziv - University of California, San FranciscoAedin C Culhane - Harvard UniversityEvan O Paull - Cancer Research CenterI K Ashok Sivakumar - Johns Hopkins UniversityAndrew J Gentles - Stanford UniversityRaunaq Malhotra - Seven Bridges GenomicsFarshad Farshidfar - University of CalgaryAntonio Colaprico - Université Libre de BruxellesJoel S Parker - University of North Carolina at Chapel HillLisle E Mose - University of North Carolina at Chapel HillNam Sy Vo - The University of Texas MD Anderson Cancer CenterJianfang LiuYuexin Liu - The University of Texas MD Anderson Cancer CenterJanet Rader - Medical College of WisconsinVarsha Dhankani - Institute for Systems BiologySheila M Reynolds - Institute for Systems BiologyReanne Bowlby - BC Cancer AgencyAndrea Califano - Cancer Research CenterAndrew D Cherniack - Massachusetts Institute of TechnologyDimitris Anastassiou - Columbia UniversityDavide Bedognetti - Sidra Medical and Research CenterYounes Mokrab - Sidra Medical and Research CenterAaron M Newman - Institute for Stem Cell Biology and Regenerative MedicineArvind Rao - The University of Texas MD Anderson Cancer CenterKen Chen - The University of Texas MD Anderson Cancer CenterAlexander Krasnitz - Cold Spring Harbor LaboratoryHai HuTathiane M Malta - Universidade de São PauloHoutan Noushmehr - Universidade de São PauloChandra Sekhar Pedamallu - Harvard UniversitySusan Bullman - Harvard UniversityAkinyemi I Ojesina - University of Alabama at BirminghamAndrew Lamb - Sage BionetworksWanding Zhou - Van Andel InstituteHui Shen - Van Andel InstituteToni K Choueiri - Harvard UniversityJohn N Weinstein - The University of Texas MD Anderson Cancer CenterJustin Guinney - Sage BionetworksJoel Saltz - Stony Brook UniversityRobert A Holt - BC Cancer AgencyCharles S Rabkin - National Cancer InstituteAlexander J Lazar - The University of Texas MD Anderson Cancer CenterJonathan S Serody - Department of Medicine and Microbiology and Lineberger Comprehensive Cancer Center, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USAElizabeth G Demicco - Sinai HospitalMary L Disis - University of WashingtonBenjamin G Vincent - Lineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA. Electronic address: benjamin.vincent@unchealth.unc.eduIlya Shmulevich - Institute for Systems Biology
- Contributors
- Cancer Genome Atlas Research NetworkDeqin Ma (Contributor) - University of Iowa, PathologyMohammed M Milhem (Contributor) - University of Iowa, Internal MedicineAaron D Bossler (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.48(4), pp.812-830.e14
- DOI
- 10.1016/j.immuni.2018.03.023
- PMID
- 29628290
- PMCID
- PMC5982584
- NLM abbreviation
- Immunity
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Grant note
- U24 CA143843 / NCI NIH HHS U24 CA180924 / NCI NIH HHS HHSN261201400008C / NCI NIH HHS U54 CA209997 / NCI NIH HHS P30 CA016086 / NCI NIH HHS U24 CA210957 / NCI NIH HHS K24 CA169004 / NCI NIH HHS R01 LM009239 / NLM NIH HHS U54 HG003079 / NHGRI NIH HHS S10 OD021764 / NIH HHS P30 CA016672 / NCI NIH HHS P20 GM130423 / NIGMS NIH HHS S10 OD012351 / NIH HHS P30 ES010126 / NIEHS NIH HHS HHSN261201400007C / NCI NIH HHS U24 CA143883 / NCI NIH HHS U24 CA210990 / NCI NIH HHS U24 CA143799 / NCI NIH HHS R35 CA197745 / NCI NIH HHS R50 CA221675 / NCI NIH HHS R01 GM045436 / NIGMS NIH HHS U24 CA143867 / NCI NIH HHS U24 CA143858 / NCI NIH HHS U24 CA143882 / NCI NIH HHS P50 CA058223 / NCI NIH HHS U54 HG003067 / NHGRI NIH HHS U24 CA143845 / NCI NIH HHS U24 CA143835 / NCI NIH HHS U54 HG003273 / NHGRI NIH HHS U24 CA143840 / NCI NIH HHS U24 CA144025 / NCI NIH HHS U24 CA143866 / NCI NIH HHS U24 CA210950 / NCI NIH HHS U24 CA210949 / NCI NIH HHS U24 CA143848 / NCI NIH HHS R01 CA163722 / NCI NIH HHS P30 CA045508 / NCI NIH HHS
- Language
- English
- Date published
- 04/17/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9984185179202771
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