Journal article
The Impact of Copy Number Deletions on General Cognitive Ability and Ventricle Size in Patients with Schizophrenia and Healthy Control Subjects
Biological psychiatry (1969), Vol.73(6), pp.540-545
03/15/2013
DOI: 10.1016/j.biopsych.2012.10.013
PMCID: PMC3582736
PMID: 23237311
Abstract
Background: General cognitive ability is usually lower in individuals with schizophrenia, partly due to genetic influences. However, the specific genetic features related to general cognitive ability are poorly understood. Individual variation in a specific type of mutation, uncommon genetic deletions, has recently been linked with both general cognitive ability and risk for schizophrenia.
Methods: We derived measures of the aggregate number of "uncommon" deletions (i.e., those occurring in 3% or less of our combined samples) and the total number of base pairs affected by these deletions in individuals with schizophrenia (n = 79) and healthy control subjects (n = 110) and related each measure to the first principal component of a large battery of cognitive tests, a common technique for characterizing general cognitive ability. These two measures of mutation load were also evaluated for relationships with total brain gray matter, white matter, and lateral ventricle volume.
Results: The groups did not differ on genetic variables. Multivariate general linear models revealed a group (control subjects vs. patients) x uncommon deletion number interaction, such that the latter variable was associated with lower general cognitive ability and larger ventricles in patients but not control subjects.
Conclusions: These data suggest that aggregate uncommon deletion burden moderates central features of the schizophrenia phenotype.
Details
- Title: Subtitle
- The Impact of Copy Number Deletions on General Cognitive Ability and Ventricle Size in Patients with Schizophrenia and Healthy Control Subjects
- Creators
- Ronald A. Yeo - University of New MexicoSteven W. Gangestad - University of New MexicoJingyu Liu - University of New MexicoStefan Ehrlich - University Hospital Carl Gustav CarusRobert J. Thoma - University of New MexicoJessica Pommy - University of New MexicoAndrew R. Mayer - University of New MexicoS. Charles Schulz - University of MinnesotaThomas H. Wassink - Roy J. and Lucille A. Carver College of MedicineEric M. Morrow - Brown UniversityJuan R. Bustillo - University of New MexicoScott R. Sponheim - Minneapolis VA Health Care SystemBeng-Choon Ho - Roy J. and Lucille A. Carver College of MedicineVince D. Calhoun - University of New Mexico
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.73(6), pp.540-545
- DOI
- 10.1016/j.biopsych.2012.10.013
- PMID
- 23237311
- PMCID
- PMC3582736
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- P20RR021938 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) Myrida/RBM RC1MH089257 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Otsuka; Otsuka Pharmaceutical Astra-Zeneca; AstraZeneca National Institutes of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) DE-FG02-08ER64581 / Department of Energy; United States Department of Energy (DOE) 5P20RR021938; 1RC1MH089257; R01EB005846 / National Institute Health R01EB005846 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Language
- English
- Date published
- 03/15/2013
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984280878502771
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