Journal article
The Impact of Cystic Fibrosis Algorithm Changes: A Case Study of Challenges and Strategies
International journal of neonatal screening, Vol.11(3), 82
09/19/2025
DOI: 10.3390/ijns11030082
PMCID: PMC12452394
PMID: 40981312
Abstract
The State Hygienic Lab at the University of Iowa (SHL) performs newborn blood spot screening (NBS) for IA, AK, ND, and SD. In October 2022, we halted in-house
DNA testing due to the unexpected nonperformance of our newly expanded variant panel. Samples were sent to a reference laboratory to ensure uninterrupted testing and by December 2022, SHL had selected an alternative test that enabled
panel expansion as envisioned. However, due to circumstances beyond our control, test implementation was severely delayed, and in-house testing was paused. These events were consequential. Firstly, our prolonged utilization of reference labs and fees was a financial strain on the lab. Secondly, our timeliness decreased significantly, and lastly, these issues were burdensome for staff. The lab overcame these problems using three strategies: effective communication; technical expertise; and staff perseverance. Finally, in Aug 2023, SHL successfully resumed in-house testing. As state labs ponder major
algorithm changes, such as the addition of next generation sequencing, the strategies we utilized can be useful during sudden setbacks. Our experience of replacing our
assay underscores the importance of emergency preparedness and partnership within the NBS community.
Details
- Title: Subtitle
- The Impact of Cystic Fibrosis Algorithm Changes: A Case Study of Challenges and Strategies
- Creators
- Jerusalem Alleyne - University of IowaKenneth Coursey - University of IowaKimberly Noble Piper - Iowa Department of Health and Human Services, Des Moines, IA 50319, USACynthia Cass - University of IowaMichael Pentella - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of neonatal screening, Vol.11(3), 82
- DOI
- 10.3390/ijns11030082
- PMID
- 40981312
- PMCID
- PMC12452394
- NLM abbreviation
- Int J Neonatal Screen
- ISSN
- 2409-515X
- eISSN
- 2409-515X
- Publisher
- MDPI
- Language
- English
- Date published
- 09/19/2025
- Academic Unit
- Central Control Hygienic Laboratory; Epidemiology; Hygienic Laboratory - Bdc
- Record Identifier
- 9984966340902771
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