Journal article
The Impact of Food on Bioavailability of Oxycodone Myristate: A Case Report
Journal of palliative care, Vol.36(3), pp.148-150
07/2021
DOI: 10.1177/0825859720981330
PMID: 33327849
Abstract
In efforts to reduce misuse of opioids, new abuse deterrent formulations of medications have been developed. Insurers increasingly give abuse-deterrent opioid formulations preferred formulary status, which can result in required formulation rotation for patients. Xtampza® (oxycodone myristate extended-release) is an abuse-deterrent opioid formulation that maintains its extended-release properties with any physical manipulation. Blood levels of oxycodone myristate extended-release (OxyM-ER) may vary with dietary caloric and fat intake.
A woman with metastatic breast carcinoma had severe myalgias and arthralgias well-managed with oxycodone hydrochloride extended-release (OxyHCl-ER) and hydrocodone/acetaminophen. A switch from OxyHCl-ER to OxyM-ER resulted in worsened pain management, decreased functional status, and a referral to palliative care (PC). Recognizing calorie-depending pharmacokinetic variability with OxyM-ER, the interdisciplinary PC team obtained a detailed dietary history from the patient, which revealed a low-fat, low-calorie healthy diet with inconsistent meals. After repeated education, the patient changed her diet and had improved pain and functional status without increasing her total daily opioid dose.
The efficacy of OxyM-ER may be compromised in patients with cancer experiencing anorexia, decreased or inconsistent food intake, or low-fat/low-calorie diets. An interdisciplinary team approach can improve pain control in the setting of "forced" formulary switches to OxyM-ER.
Details
- Title: Subtitle
- The Impact of Food on Bioavailability of Oxycodone Myristate: A Case Report
- Creators
- Theodore Pham Nguyen - University of IowaYuya Hagiwara - University of Iowa Hospitals and ClinicsCarla Pies - University of Iowa Hospitals and ClinicsKashelle Lockman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of palliative care, Vol.36(3), pp.148-150
- DOI
- 10.1177/0825859720981330
- PMID
- 33327849
- ISSN
- 0825-8597
- eISSN
- 2369-5293
- Language
- English
- Date published
- 07/2021
- Academic Unit
- Pharmacy Practice and Science; Office of Consultation and Research in Medical Education; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984359903802771
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