The Impact of Recent Alcohol Use on Genome Wide DNA Methylation Signatures

Robert A Philibert; Jeffrey M Plume; Frederick X Gibbons; Gene H Brody; Steven R. H Beach

doi:10.3389/fgene.2012.00054

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The Impact of Recent Alcohol Use on Genome Wide DNA Methylation Signatures

Journal article

Open access

Peer reviewed

The Impact of Recent Alcohol Use on Genome Wide DNA Methylation Signatures

Robert A Philibert, Jeffrey M Plume, Frederick X Gibbons, Gene H Brody and Steven R. H Beach

Frontiers in genetics, Vol.3, pp.54-54

2012

DOI: 10.3389/fgene.2012.00054

PMCID: PMC3322340

PMID: 22514556

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Abstract

Chronic alcohol intake is associated with a wide variety of adverse health outcomes including depression, diabetes, and heart disease. Unfortunately, the molecular mechanisms through which these effects are conveyed are not clearly understood. To examine the potential role of epigenetic factors in this process, we examined the relationship of recent alcohol intake to genome wide methylation patterns using the Illumina 450 Methylation Bead Chip and lymphoblast DNA derived from 165 female subjects participating in the Iowa Adoption Studies. We found that the pattern of alcohol use over the 6-months immediately prior to phlebotomy was associated with, severity-dependent changes in the degree of genome wide methylation that preferentially hypermethylate the central portion of CpG islands with methylation at cg05600126, a probe in ABR, and the 5′ untranslated region of BLCAP attaining genome wide significance in two point and sliding window analyses of probe methylation data, respectively. We conclude that recent alcohol use is associated with widespread changes in DNA methylation in women and that further study to confirm these findings and determine their relationship to somatic function are in order.

epilepsy

Genetics

ketogenic diet

neurological disorders

neuroplasticity

Details

Title: Subtitle: The Impact of Recent Alcohol Use on Genome Wide DNA Methylation Signatures
Creators: Robert A Philibert - Neuroscience and Genetics Programs, The University of Iowa
Jeffrey M Plume - Neuroscience and Genetics Programs, The University of Iowa
Frederick X Gibbons - Department of Psychological and Brain Sciences, Dartmouth College
Gene H Brody - Center for Family Research, The University of Georgia
Steven R. H Beach - Center for Family Research, The University of Georgia
Resource Type: Journal article
Publication Details: Frontiers in genetics, Vol.3, pp.54-54
DOI: 10.3389/fgene.2012.00054
PMID: 22514556
PMCID: PMC3322340
NLM abbreviation: Front Genet
ISSN: 1664-8021
eISSN: 1664-8021
Publisher: Frontiers Research Foundation
Language: English
Date published: 2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984004085602771

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