Journal article
The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture
Inflammation research, Vol.72(1), pp.9-11
01/2023
DOI: 10.1007/s00011-022-01661-4
Abstract
Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.
Details
- Title: Subtitle
- The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture
- Creators
- Cale A JacobsZachary M OlsenLucas S MarchandVirginia B KrausDonald D AndersonJustin Haller
- Resource Type
- Journal article
- Publication Details
- Inflammation research, Vol.72(1), pp.9-11
- DOI
- 10.1007/s00011-022-01661-4
- ISSN
- 1023-3830
- eISSN
- 1420-908X
- Grant note
- DOI: 10.13039/100000980, name: Arthritis Foundation
- Language
- English
- Electronic publication date
- 10/29/2022
- Date published
- 01/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Industrial and Systems Engineering; Orthopedics and Rehabilitation
- Record Identifier
- 9984308559902771
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