Journal article
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
PLoS genetics, Vol.11(10), pp.e1005378-42
10/2015
DOI: 10.1371/journal.pgen.1005378
PMCID: PMC4591371
PMID: 26426971
Abstract
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
Details
- Title: Subtitle
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Creators
- Thomas W Winkler - Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, GermanyDavid A Bennett - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of AmericaJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of AmericaAnne E Justice - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaMariaelisa Graff - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaLlilda Barata - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaMary F Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaSu Chu - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaJacek Czajkowski - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaTõnu Esko - Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of AmericaTove Fall - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, SwedenTuomas O Kilpeläinen - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United KingdomYingchang Lu - The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaReedik Mägi - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomEvelin Mihailov - Estonian Genome Center, Univeristy of Tartu, Tartu, EstoniaTune H Pers - Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of AmericaSina Rüeger - Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, SwitzerlandAlexander Teumer - Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, GermanyGeorg B Ehret - Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of AmericaNancy L Heard-Costa - Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of AmericaTeresa Ferreira - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomJuha Karjalainen - University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The NetherlandsVasiliki Lagou - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United KingdomAnubha Mahajan - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomMichael D Neinast - Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of AmericaInga Prokopenko - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Hammersmith Hospital, London, United Kingdom; Department of Genomics of Common Diseases, School of Public Health, Imperial College London, London, United KingdomJeannette Simino - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaTanya M Teslovich - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaRick Jansen - Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the NetherlandsHarm-Jan Westra - Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of AmericaCharles C White - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of AmericaDevin Absher - HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of AmericaTarunveer S Ahluwalia - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center A/S, Gentofte, Denmark; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, DenmarkShafqat Ahmad - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, SwedenEva Albrecht - Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyAlexessander Couto Alves - Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United KingdomJennifer L Bragg-Gresham - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaAnton J M de Craen - Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsJoshua C Bis - Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of AmericaAmélie Bonnefond - CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, FranceGabrielle Boucher - Montreal Heart Institute, Montréal, Québec, CanadaGemma Cadby - Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, AustraliaYu-Ching Cheng - VA Maryland Health Care System, Baltimore, Maryland, United States of America; University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of AmericaCharleston W K Chiang - Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of AmericaGraciela Delgado - Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, GermanyAyse Demirkan - Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsNicole Dueker - Universiy of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of AmericaNiina Eklund - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, FinlandGudny Eiriksdottir - Icelandic Heart Association, Kopavogur, IcelandJoel Eriksson - Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenBjarke Feenstra - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkKrista Fischer - Estonian Genome Center, Univeristy of Tartu, Tartu, EstoniaFrancesca Frau - Department of Health Sciences, University of Milan, Milan, Italy; Filarete Foundation, Genomic and Bioinformatics Unit, Milano, ItalyTessel E Galesloot - Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The NetherlandsFrank Geller - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkAnuj Goel - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United KingdomMathias Gorski - Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany; Department of Nephrology, University Hospital Regensburg, Regensburg, GermanyTanja B Grammer - Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, GermanyStefan Gustafsson - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, SwedenSaskia Haitjema - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The NetherlandsJouke-Jan Hottenga - Department of Biological Psychology, VU University, Amsterdam, The NetherlandsJennifer E Huffman - National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, ScotlandAnne U Jackson - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaKevin B Jacobs - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of AmericaÅsa Johansson - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenMarika Kaakinen - Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom; Institute of Health Sciences, University of Oulu, Oulu, FinlandMarcus E Kleber - Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, GermanyJari Lahti - Folkhälsan Research Centre, Helsinki, Finland; Institute of Behavioural Sciences, University of Helsinki, Helsinki, FinlandIrene Mateo Leach - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, NetherlandsBenjamin Lehne - Department of Epidemiology and Biostatistics, Imperial College London, London, United KingdomYoufang Liu - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of AmericaKen Sin Lo - Montreal Heart Institute, Montréal, Québec, CanadaMattias Lorentzon - Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenJian'an Luan - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United KingdomPamela A F Madden - Washington University Medical School, St. Louis, Missouri, United States of AmericaMassimo Mangino - Department of Twin Research and Genetic Epidemiology, King's College London, London, United KingdomBarbara McKnight - Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Biostatistics, University of Washington, Seattle, Washington, United States of AmericaCarolina Medina-Gomez - Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsKeri L Monda - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; The Center for Observational Research, Amgen Inc., Thousand Oaks, California, United States of AmericaMay E Montasser - Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of AmericaGabriele Müller - Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, GermanyMartina Müller-Nurasyid - Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, GermanyIlja M Nolte - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The NetherlandsKalliope Panoutsopoulou - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United KingdomLaura Pascoe - Institute of Cell & Molecular Biosciences, Newcastle University, Newcastle, United KingdomLavinia Paternoster - MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United KingdomNigel W Rayner - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United KingdomFrida Renström - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, SwedenFederica Rizzi - Department of Health Sciences, University of Milan, Milan, Italy; Filarete Foundation, Genomic and Bioinformatics Unit, Milano, ItalyLynda M Rose - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of AmericaKathy A Ryan - Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of AmericaPerttu Salo - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, FinlandSerena Sanna - Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, ItalyHubert Scharnagl - Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, AustriaJianxin Shi - National Cancer Institute, Bethesda, Maryland, United States of AmericaAlbert Vernon Smith - Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, IcelandLorraine Southam - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United KingdomAlena Stančáková - Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, FinlandValgerdur Steinthorsdottir - deCODE Genetics, Amgen inc., Reykjavik, IcelandRona J Strawbridge - Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SwedenYun Ju Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaIoanna Tachmazidou - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United KingdomToshiko Tanaka - Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of AmericaGudmar Thorleifsson - deCODE Genetics, Amgen inc., Reykjavik, IcelandStella Trompet - Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The NetherlandsNatalia Pervjakova - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland; Institute of Cell and Molecular Biology, Department of Biotechnology, University of Tartu, Tartu, Estonia; University of Helsinki, Helsinki, FinlandJonathan P Tyrer - Department of Oncology, University of Cambridge, Cambridge, United KingdomLiesbeth Vandenput - Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenSander W van der Laan - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The NetherlandsNathalie van der Velde - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, The NetherlandsJessica van Setten - Department of Medical Genetics, University Medical Center Utrecht, Utrecht, NetherlandsJana V van Vliet-Ostaptchouk - University of Groningen, University Medical Center Groningen, Department of Endocrinology, Groningen, The NetherlandsNiek Verweij - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, NetherlandsEfthymia Vlachopoulou - Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, FinlandLindsay L Waite - HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of AmericaSophie R Wang - Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, United States of America; Divisions of Genetics and Endocrinology and Program in Genomics, Boston's Children's Hospital, Boston, Massachusetts, United States of AmericaZhaoming Wang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of AmericaSarah H Wild - Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, ScotlandChristina Willenborg - DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, GermanyAndrew Wong - MRC Unit for Lifelong Health & Ageing at UCL, London, United KingdomJames F Wilson - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, ScotlandJian Yang - Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, AustraliaLoïc Yengo - CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, FranceLaura M Yerges-Armstrong - Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of AmericaLei Yu - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of AmericaWeihua Zhang - Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United KingdomJing Hua Zhao - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United KingdomEhm A Andersson - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkStephan J L Bakker - University of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, NetherlandsDamiano Baldassarre - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, ItalyKarina Banasik - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkMatteo Barcella - Department of Health Sciences, University of Milan, Milan, ItalyCristina Barlassina - Department of Health Sciences, University of Milan, Milan, ItalyClaire Bellis - Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, AustraliaPaola Benaglio - Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America; Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandJohn Blangero - Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of AmericaMatthias Blüher - University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany; University of Leipzig, Department of Medicine, Leipzig, GermanyFabrice Bonnet - University Rennes 1, Rennes, FranceLori L Bonnycastle - Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of AmericaHeather A Boyd - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkMarcel Bruinenberg - University of Groningen, University Medical Center Groningen, The LifeLines Cohort Study, Groningen, The NetherlandsAron S Buchman - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of AmericaHarry Campbell - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, ScotlandYii-Der Ida Chen - Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of AmericaPeter S Chines - Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of AmericaSimone Claudi-Boehm - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, GermanyJohn Cole - VA Maryland Health Care System, Baltimore, Maryland, United States of America; Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of AmericaFrancis S Collins - Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of AmericaEco J C de Geus - Department of Biological Psychology, VU University, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The NetherlandsLisette C P G M de Groot - Department of Human Nutrition, Wageningen University, Wageningen, The NetherlandsMaria Dimitriou - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; Department of Dietetics-Nutrition, Harokopio University, Athens, GreeceJubao Duan - NorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of AmericaStefan Enroth - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenElodie Eury - CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, FranceAliki-Eleni Farmaki - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, GreeceNita G Forouhi - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United KingdomNele Friedrich - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyPablo V Gejman - NorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of AmericaBruna Gigante - Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenNicola Glorioso - Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari, ItalyAlan S Go - Kaiser Permanente, Division of Research, Oakland, California, United States of AmericaOmri Gottesman - The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaJürgen Gräßler - Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, GermanyHarald Grallert - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, GermanyNiels Grarup - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkYu-Mei Gu - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, BelgiumLinda Broer - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsAnnelies C Ham - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsTorben Hansen - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, DenmarkTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, United States of America; National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of AmericaCatharina A Hartman - University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The NetherlandsMaija Hassinen - Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandNicholas Hastie - MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, ScotlandAndrew T Hattersley - Institue of Biomedical & Clinical Science, University of Exeter, Exeter, United KingdomAndrew C Heath - Washington University Medical School, St. Louis, Missouri, United States of AmericaAnjali K Henders - QIMR Bergofer Medical Research Institute, Brisbane, Queensland, AustraliaDena Hernandez - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of AmericaHans Hillege - University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, NetherlandsOddgeir Holmen - Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, NorwayKees G Hovingh - Department Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsJennie Hui - Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia; School of Population Health, University of Western Australia, Nedlands, Western Australia, AustraliaLise L Husemoen - Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, DenmarkNina Hutri-Kähönen - Department of Pediatrics, University of Tampere School of Medicine, Tampere, Finland; Department of Pediatrics,Tampere University Hospital, Tampere, FinlandPirro G Hysi - Department of Twin Research and Genetic Epidemiology, King's College London, London, United KingdomThomas Illig - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany; Institute of Human Genetics, Hannover Medical School, Hanover, GermanyPhilip L De Jager - Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America; Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts,United States of AmericaShapour Jalilzadeh - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United KingdomTorben Jørgensen - Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, University of Aalborg, Aalborg, DenmarkJ Wouter Jukema - Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The NetherlandsMarkus Juonala - Division of Medicine, Turku University Hospital, Turku, Finland; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Medicine, University of Turku, Turku, FinlandStavroula Kanoni - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United KingdomMaria Karaleftheri - Echinos Medical Centre, Echinos, GreeceKay Tee Khaw - Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, United KingdomLeena Kinnunen - Department of Health, National Institute for Health and Welfare, Helsinki, FinlandSteven J Kittner - VA Maryland Health Care System, Baltimore, Maryland, United States of America; Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of AmericaWolfgang Koenig - Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, GermanyIvana Kolcic - Department of Public Health, Faculty of Medicine, University of Split, Split, CroatiaPeter Kovacs - University of Leipzig, IFB Adiposity Diseases, Leipzig, GermanyNikolaj T Krarup - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkWolfgang Kratzer - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, GermanyJanine Krüger - Department of Medicine A, University Medicine Greifswald, Greifswald, GermanyDiana Kuh - MRC Unit for Lifelong Health & Ageing at UCL, London, United KingdomMeena Kumari - Department of Epidemiology and Public Health, UCL, London, United KingdomTheodosios Kyriakou - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United KingdomClaudia Langenberg - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; Department of Epidemiology and Public Health, UCL, London, United KingdomLars Lannfelt - Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, SwedenChiara Lanzani - Chair of Nephrology, Università Vita Salute San Raffaele, Segrate (Milan), Italy; Genomics of Renal Disease and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Segrate (Milan), ItalyVaneet Lotay - Department of Biological Sciences, University of Calgary, Calgary, Alberta, CanadaLenore J Launer - National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of AmericaKarin Leander - Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenJaana Lindström - Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, FinlandAllan Linneberg - Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, DenmarkYan-Ping Liu - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, BelgiumStéphane Lobbens - CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, FranceRobert Luben - Strangeways Research Laboratory Wort's Causeway, Cambridge, United KingdomValeriya Lyssenko - Steno Diabetes Center A/S, Gentofte, Denmark; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, SwedenSatu Männistö - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, FinlandPatrik K Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenWendy L McArdle - School of Social and Community Medicine, University of Bristol, Bristol, United KingdomCristina Menni - Department of Twin Research and Genetic Epidemiology, King's College London, London, United KingdomSigrun Merger - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, GermanyLili Milani - Estonian Genome Center, Univeristy of Tartu, Tartu, EstoniaGrant W Montgomery - QIMR Bergofer Medical Research Institute, Brisbane, Queensland, AustraliaAndrew P Morris - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Biostatistics, University of Liverpool, Liverpool, United KingdomNarisu Narisu - Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of AmericaMari Nelis - Estonian Genome Center, Univeristy of Tartu, Tartu, EstoniaKen K Ong - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom; Department of Paediatrics, University of Cambridge, Cambridge, United KingdomAarno Palotie - Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts, United States of AmericaLouis Pérusse - Department of Kinesiology, Laval University, Québec City, Québec, Canada; Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, CanadaIrene Pichler - Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, GermanyMaria G Pilia - Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, ItalyAnneli Pouta - Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland; Department of Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, FinlandMyriam Rheinberger - Department of Nephrology, University Hospital Regensburg, Regensburg, GermanyRasmus Ribel-Madsen - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkMarcus Richards - MRC Unit for Lifelong Health & Ageing at UCL, London, United KingdomKenneth M Rice - Department of Biostatistics, University of Washington, Seattle, Washington, United States of AmericaTreva K Rice - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaCarlo Rivolta - Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandVeikko Salomaa - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, FinlandAlan R Sanders - NorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of AmericaMark A Sarzynski - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of AmericaSalome Scholtens - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The NetherlandsRobert A Scott - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United KingdomWilliam R Scott - Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United KingdomSylvain Sebert - Institute of Health Sciences, University of Oulu, Oulu, FinlandSebanti Sengupta - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaBengt Sennblad - Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, SwedenThomas Seufferlein - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, GermanyAngela Silveira - Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SwedenP Eline Slagboom - Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The NetherlandsJan H Smit - Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the NetherlandsThomas H Sparsø - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkKathleen Stirrups - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United KingdomRonald P Stolk - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The NetherlandsHeather M Stringham - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaMorris A Swertz - University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The NetherlandsAmy J Swift - Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of AmericaAnn-Christine Syvänen - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, SwedenSian-Tsung Tan - Ealing Hospital NHS Trust, Middlesex, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United KingdomBarbara Thorand - Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, GermanyAnke Tönjes - University of Leipzig, Department of Medicine, Leipzig, GermanyAngelo Tremblay - Department of Kinesiology, Laval University, Québec City, Québec, CanadaEmmanouil Tsafantakis - Anogia Medical Centre, Anogia, GreecePeter J van der Most - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The NetherlandsUwe Völker - Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, GermanyMarie-Claude Vohl - Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada; School of Nutrition, Laval University, Québec City, Québec,CanadaJudith M Vonk - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The NetherlandsMelanie Waldenberger - DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyRyan W Walker - The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaRoman Wennauer - Department of Clinical Chemistry, Ulm University Medical Centre, Ulm, GermanyElisabeth Widén - Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, FinlandGonneke Willemsen - Department of Biological Psychology, VU University, Amsterdam, The NetherlandsTom Wilsgaard - Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, NorwayAlan F Wright - MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, ScotlandM Carola Zillikens - Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsSuzanne C van Dijk - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsNatasja M van Schoor - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; VUMC, Department of Epidemiology and Biostatistics, Amsterdam, The NetherlandsFolkert W Asselbergs - Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, University College London, London, United KingdomPaul I W de Bakker - Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Department of Epidemiology, University Medical Center, Utrecht, The NetherlandsJacques S Beckmann - Swiss Institute of Bioinformatics, Lausanne, SwitzerlandJohn Beilby - Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, AustraliaRichard N Bergman - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of AmericaSven Bergmann - Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandCarsten A Böger - Department of Nephrology, University Hospital Regensburg, Regensburg, GermanyBernhard O Boehm - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany; Imperial College London, London, United Kingdom; Lee Kong Chian School of Medicine, Singapore, Singapore; Nanyang Technological University, Singapore, SingaporeEric Boerwinkle - Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of AmericaDorret I Boomsma - Department of Biological Psychology, VU University, Amsterdam, The NetherlandsStefan R Bornstein - Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, GermanyErwin P Bottinger - The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of AmericaClaude Bouchard - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of AmericaJohn C Chambers - Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom; Imperial College Healthcare NHS Trust, London, United KingdomStephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of AmericaDaniel I Chasman - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of AmericaFrancesco Cucca - Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy; University of Sassari, Sassari, ItalyDaniele Cusi - Department of Health Sciences, University of Milan, Milan, Italy; Institute of Biomedical Technologies, National Institute of Research, Segrate-Milano, ItalyGeorge Dedoussis - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, GreeceJeanette Erdmann - DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, GermanyJohan G Eriksson - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Folkhälsan Research Centre, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, FinlandDenis A Evans - Rush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of AmericaUlf de Faire - Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenMartin Farrall - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Durrer Center for Cardiogenetic Research, Amsterdam, The NetherlandsLuigi Ferrucci - Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of AmericaIan Ford - Robertson Center for Biostatistics, University of Glasgow, Glasgow, United KingdomLude Franke - University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, NetherlandsPaul W Franks - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden; Department of Public Health & Clinical Medicine, Umeå University Hospital, Umeå, Sweden, Umeå, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of AmericaPhilippe Froguel - CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, FranceRon T Gansevoort - University of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, NetherlandsChristian Gieger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyHenrik Grönberg - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenVilmundur Gudnason - Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, IcelandUlf Gyllensten - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenPer Hall - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenAnders Hamsten - Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, SwedenPim van der Harst - University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The NetherlandsCaroline Hayward - MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, ScotlandMarkku Heliövaara - Department of Health, National Institute for Health and Welfare, Helsinki, FinlandChristian Hengstenberg - DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, München, GermanyAndrew A Hicks - Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, GermanyAroon Hingorani - Institute of Cardiovascular Science, University College London, London, United KingdomAlbert Hofman - Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The NetherlandsFrank Hu - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of AmericaHeikki V Huikuri - Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, FinlandKristian Hveem - Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, NorwayAlan L James - Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AustraliaJoanne M Jordan - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of AmericaAntti Jula - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, FinlandMika Kähönen - Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, FinlandEero Kajantie - Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandSekar Kathiresan - Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of AmericaLambertus A L M Kiemeney - Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands; Radboud university medical center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, The NetherlandsMika Kivimaki - Department of Epidemiology and Public Health, UCL, London, United KingdomPaul B Knekt - National Institute for Health and Welfare, Helsinki, FinlandHeikki A Koistinen - National Institute for Health and Welfare, Helsinki, Finland; University of Helsinki and Helsinki University Central Hospital, Department of Medicine and Abdominal Center: Endocrinology, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, FinlandJaspal S Kooner - Ealing Hospital NHS Trust, Middlesex, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United KingdomSeppo Koskinen - Department of Health, National Institute for Health and Welfare, Helsinki, FinlandJohanna Kuusisto - Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, FinlandWinfried Maerz - Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, AustriaNicholas G Martin - QIMR Bergofer Medical Research Institute, Brisbane, Queensland, AustraliaMarkku Laakso - Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, FinlandTimo A Lakka - Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, FinlandTerho Lehtimäki - Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, FinlandGuillaume Lettre - Montreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, CanadaDouglas F Levinson - Stanford University, Stanford, California, United States of AmericaLars Lind - Department of Medical Sciences, Uppsala University, Uppsala, SwedenMarja-Liisa Lokki - Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, FinlandPekka Mäntyselkä - Primary Health Care Unit, Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland; Primary Health Care Unit, Kuopio University Hospital, Kuopio, FinlandMads Melbye - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of AmericaAndres Metspalu - Estonian Genome Center, Univeristy of Tartu, Tartu, EstoniaBraxton D Mitchell - University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of AmericaFrans L Moll - Department of Surgery, University Medical Center Utrecht, Utrecht, NetherlandsArthur W Musk - Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AustraliaMarkku S Nieminen - HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, FinlandInger Njølstad - Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, NorwayClaes Ohlsson - Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenAlbertine J Oldehinkel - University of Groningen, University Medical Center, Interdisciplinary Center Psychopathology and Emotion Regulation, Groningen, The NetherlandsBen A Oostra - Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsLyle J Palmer - School of Public Health, University of Adelaide, Adelaide, South Australia, Australia; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, AustraliaJames S Pankow - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of AmericaGerard Pasterkamp - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The NetherlandsNancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenOluf Pedersen - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkBrenda W Penninx - Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the NetherlandsMarkus Perola - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, FinlandAnnette Peters - DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyOzren Polašek - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland; Department of Public Health, Faculty of Medicine, University of Split, Split, CroatiaPeter P Pramstaller - Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany; Department of Neurology, General Central Hospital, Bolzano, ItalyBruce M Psaty - Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seatte, Washington, United States of AmericaLu Qi - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of AmericaThomas Quertermous - Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of AmericaOlli T Raitakari - Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandTuomo Rankinen - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of AmericaRainer Rauramaa - Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FinlandPaul M Ridker - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of AmericaJohn D Rioux - Montreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, CanadaFernando Rivadeneira - Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsJerome I Rotter - Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of AmericaIgor Rudan - Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, ScotlandHester M den Ruijter - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The NetherlandsJuha Saltevo - Department of Medicine, Central Finland Central Hospital, Jyväskylä, FinlandNaveed Sattar - BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United KingdomHeribert Schunkert - DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, München, GermanyPeter E H Schwarz - Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, GermanyAlan R Shuldiner - Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, United States of AmericaJuha Sinisalo - HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, FinlandHarold Snieder - University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The NetherlandsThorkild I A Sørensen - Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, DenmarkTim D Spector - Department of Twin Research and Genetic Epidemiology, King's College London, London, United KingdomJan A Staessen - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; R & D VitaK Group, Maastricht University, Maastricht, The NetherlandsBandinelli Stefania - Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, ItalyUnnur Thorsteinsdottir - deCODE Genetics, Amgen inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, IcelandMichael Stumvoll - University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany; University of Leipzig, Department of Medicine, Leipzig, GermanyJean-Claude Tardif - Montreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, CanadaElena Tremoli - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, ItalyJaakko Tuomilehto - Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria; Instituto de Investigacion Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi ArabiaAndré G Uitterlinden - Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The NetherlandsMatti Uusitupa - Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland; Research Unit, Kuopio University Hospital, Kuopio, FinlandAndré L M Verbeek - Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The NetherlandsSita H Vermeulen - Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands; Department of Human Genetics, Radboud university medical center, Nijmegen, The NetherlandsJorma S Viikari - Department of Medicine, University of Turku, Turku, FinlandVeronique Vitart - MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, ScotlandHenry Völzke - Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, GermanyPeter Vollenweider - Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, SwitzerlandGérard Waeber - Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, SwitzerlandMark Walker - Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Institute of Cellular Medicine, Newcastle University, Newcastle, United KingdomHenri Wallaschofski - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, GermanyNicholas J Wareham - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United KingdomHugh Watkins - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United KingdomEleftheria Zeggini - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United KingdomAravinda Chakravarti - Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of AmericaDeborah J Clegg - Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of AmericaL Adrienne Cupples - National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of AmericaPenny Gordon-Larsen - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaCashell E Jaquish - National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, United States of AmericaD C Rao - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaGoncalo R Abecasis - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaThemistocles L Assimes - Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of AmericaInês Barroso - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, United Kingdom; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, United KingdomSonja I Berndt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of AmericaMichael Boehnke - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of AmericaPanos Deloukas - Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi ArabiaCaroline S Fox - National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of AmericaLeif C Groop - Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, FinlandDavid J Hunter - Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of AmericaErik Ingelsson - Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of AmericaRobert C Kaplan - Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York, United States of AmericaMark I McCarthy - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Oxford, United KingdomKaren L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of AmericaJeffrey R O'Connell - Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of AmericaDavid Schlessinger - National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of AmericaDavid P Strachan - Population Health Research Institute, St George's, University of London, London, United KingdomKari Stefansson - deCODE Genetics, Amgen inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, IcelandCornelia M van Duijn - Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Center for Medical Systems Biology, Leiden, The NetherlandsJoel N Hirschhorn - Broad InstituteCecilia M Lindgren - Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomIris M Heid - Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyKari E North - Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of AmericaIngrid B Borecki - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of AmericaZoltán Kutalik - Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland; Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandRuth J F Loos - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
- Resource Type
- Journal article
- Publication Details
- PLoS genetics, Vol.11(10), pp.e1005378-42
- DOI
- 10.1371/journal.pgen.1005378
- PMID
- 26426971
- PMCID
- PMC4591371
- NLM abbreviation
- PLoS Genet
- ISSN
- 1553-7390
- eISSN
- 1553-7404
- Publisher
- Public Library Science; United States
- Grant note
- R01 HL045670 / NHLBI NIH HHS R01 DK062370 / NIDDK NIH HHS U01 DK062418 / NIDDK NIH HHS R01 DA012854 / NIDA NIH HHS U01 HL105198 / NHLBI NIH HHS R01 NS045012 / NINDS NIH HHS R01 DK072193 / NIDDK NIH HHS R01 DK091718 / NIDDK NIH HHS U01 HG004402 / NHGRI NIH HHS R01 AA013321 / NIAAA NIH HHS R01 AG030146 / NIA NIH HHS R56 DA012854 / NIDA NIH HHS P60 DK020541 / NIDDK NIH HHS HHSN268200782096C / NHGRI NIH HHS M01 RR016500 / NCRR NIH HHS R56 AG023629 / NIA NIH HHS P30 DK020541 / NIDDK NIH HHS R01 HL103612 / NHLBI NIH HHS MR/K002414/1 / Medical Research Council RC2 MH089995 / NIMH NIH HHS R01 MH059587 / NIMH NIH HHS R01 AA014041 / NIAAA NIH HHS G0601966 / Medical Research Council R01 HL059367 / NHLBI NIH HHS Z01 HG000024 / Intramural NIH HHS MC_U106179472 / Medical Research Council U01 HG004446 / NHGRI NIH HHS MR/N01104X/1 / Medical Research Council MC_UU_12015/2 / Medical Research Council MR/K013351/1 / Medical Research Council N01HC55022 / NHLBI NIH HHS MC_PC_U127561128 / Medical Research Council R01 HL080467 / NHLBI NIH HHS R01 AG008724 / NIA NIH HHS 20308 / Versus Arthritis T32 HL007055 / NHLBI NIH HHS R01 MH059571 / NIMH NIH HHS P30 DK063491 / NIDDK NIH HHS R01 HL087652 / NHLBI NIH HHS R01 HL071981 / NHLBI NIH HHS Wellcome Trust U01 HL080295 / NHLBI NIH HHS R01 HL120393 / NHLBI NIH HHS MC_UU_12015/5 / Medical Research Council N01HC85083 / NHLBI NIH HHS RF1 AG015819 / NIA NIH HHS U01 HG004423 / NHGRI NIH HHS R01 MH060879 / NIMH NIH HHS N01HG65403 / NHGRI NIH HHS R01 HL117078 / NHLBI NIH HHS R01 AG023629 / NIA NIH HHS R01 HL043851 / NHLBI NIH HHS 14136 / Cancer Research UK MC_U106179471 / Medical Research Council UM1 CA182913 / NCI NIH HHS N01HC55019 / NHLBI NIH HHS P60 AR030701 / NIAMS NIH HHS G1002319 / Medical Research Council U01 CA098233 / NCI NIH HHS 098395 / Wellcome Trust N01AG12109 / NIA NIH HHS U01 HL072515 / NHLBI NIH HHS HHSN268201200036C / NHLBI NIH HHS R01 MH081802 / NIMH NIH HHS N01HC85082 / NHLBI NIH HHS MC_UU_12019/1 / Medical Research Council R01 AG017917 / NIA NIH HHS U01 HG004438 / NHGRI NIH HHS R01 DK089256 / NIDDK NIH HHS R01 HL086694 / NHLBI NIH HHS R01 DK075787 / NIDDK NIH HHS U01 HL084756 / NHLBI NIH HHS G1001799 / Medical Research Council P30 DK020572 / NIDDK NIH HHS R01 MH059588 / NIMH NIH HHS 098381 / Wellcome Trust RG/13/2/30098 / British Heart Foundation T32 AG000219 / NIA NIH HHS R01 HL087679 / NHLBI NIH HHS G1000143 / Medical Research Council N01HC85079 / NHLBI NIH HHS R01 HL036310 / NHLBI NIH HHS R01 MH081800 / NIMH NIH HHS RL1 MH083268 / NIMH NIH HHS R01 AG013196 / NIA NIH HHS R01 MH059566 / NIMH NIH HHS R01 AA007535 / NIAAA NIH HHS N01HC55018 / NHLBI NIH HHS R01 DK075681 / NIDDK NIH HHS R01 AG028555 / NIA NIH HHS P60 AR049465 / NIAMS NIH HHS U01 HG004436 / NHGRI NIH HHS P2C HD050924 / NICHD NIH HHS UL1 RR025005 / NCRR NIH HHS MC_UU_12015/1 / Medical Research Council U01 MH079470 / NIMH NIH HHS N01HC55015 / NHLBI NIH HHS R01 AG011101 / NIA NIH HHS U54 RR020278 / NCRR NIH HHS G0000934 / Medical Research Council P30 DK072488 / NIDDK NIH HHS U24 MH068457 / NIMH NIH HHS N01HC25195 / NHLBI NIH HHS R01 MH059565 / NIMH NIH HHS N01HC85081 / NHLBI NIH HHS P30 AG010161 / NIA NIH HHS 098017 / Wellcome Trust G0700931 / Medical Research Council RG/10/12/28456 / British Heart Foundation G0401527 / Medical Research Council U01 GM074518 / NIGMS NIH HHS N01HC85086 / NHLBI NIH HHS R01 MH060870 / NIMH NIH HHS N01HC55016 / NHLBI NIH HHS R01 AG015819 / NIA NIH HHS R01 MH061675 / NIMH NIH HHS U01 MH079469 / NIMH NIH HHS R01 HG002651 / NHGRI NIH HHS R01 MH067257 / NIMH NIH HHS U01 NS069208 / NINDS NIH HHS RC2 MH089951 / NIMH NIH HHS R01 MH063706 / NIMH NIH HHS N02HL64278 / NHLBI NIH HHS N01HC85080 / NHLBI NIH HHS R01 MD009164 / NIMHD NIH HHS R01 MH059586 / NIMH NIH HHS U01 HL084729 / NHLBI NIH HHS P30 DK046200 / NIDDK NIH HHS R01 AA013326 / NIAAA NIH HHS N01HC55021 / NHLBI NIH HHS UL1 TR000124 / NCATS NIH HHS R01 AA013320 / NIAAA NIH HHS HHSN268200800007C / NHLBI NIH HHS N01HC55222 / NHLBI NIH HHS N01AG12100 / NIA NIH HHS R01 AG010175 / NIA NIH HHS R01 DK093757 / NIDDK NIH HHS G0600705 / Medical Research Council R01 CA047988 / NCI NIH HHS MC_UP_A100_1003 / Medical Research Council R01 HL105756 / NHLBI NIH HHS N01HC55020 / NHLBI NIH HHS U01 DK062370 / NIDDK NIH HHS R01 HL087676 / NHLBI NIH HHS F32 AR059469 / NIAMS NIH HHS T32 HL091823 / NHLBI NIH HHS R01 HL087641 / NHLBI NIH HHS R01 HL087647 / NHLBI NIH HHS R37 AG013196 / NIA NIH HHS
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025337402771
Metrics
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