Journal article
The Influence of Multiple Chronic Conditions on Symptom Clusters in People With Solid Tumor Cancers
Cancer nursing, Vol.45(1), pp.E279-E290
01/01/2022
DOI: 10.1097/NCC.0000000000000915
PMCID: PMC8357857
PMID: 33577204
Abstract
Background People with cancer who also have multiple chronic conditions (MCCs) experience co-occurring symptoms known as symptom clusters. Objective To describe MCC and symptom clusters in people with cancer and to evaluate the relationships between MCCs and symptom severity, symptom interference with daily life, and quality of life (QoL). Methods Weekly over a 3-week chemotherapy cycle, 182 adults with solid tumor cancer receiving chemotherapy completed measures of symptom severity, symptom interference with daily life, and QoL. Medical records reviewed to count number of MCCs in addition to cancer. Exploratory factor analysis was performed to identify symptom clusters. The relationships between the number of MCCs and the outcomes (symptom severity and symptom interference with daily life and QoL) at each time point were examined using the chi(2) test. Longitudinal changes in outcomes were examined graphically. Results The number of MCCs ranged from 0 to 9, but most participants (62.1%) had 2 or fewer MCCs. Obesity was the most prevalent chronic condition. Four symptom clusters were identified: nutrition, neurocognitive, abdominal discomfort, and respiratory clusters. At each time point, no significant differences were found for MCCs and any outcome. However, symptom severity in all the symptom clusters, symptom interference with daily life, and QoL demonstrated a worsening in the week following chemotherapy. Conclusion A majority of our sample had 2 or fewer MCCs, and MCCs did contribute to patient outcomes. Rather, timing of chemotherapy cycle had the greatest influence of patient outcomes. Implications for Practice Additional support on day 7 of chemotherapy treatment is needed for people with MCCs.
Details
- Title: Subtitle
- The Influence of Multiple Chronic Conditions on Symptom Clusters in People With Solid Tumor Cancers
- Creators
- Seyedehtanaz Saeidzadeh - University of IowaYelena Perkhounkova - University of IowaStephanie Gilbertson-White - Univ Iowa, Coll Nursing, 326 CNB,50 Newton Rd, Iowa City, IA 52242 USACatherine H. Cherwin - Univ Iowa, Coll Nursing, 326 CNB,50 Newton Rd, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Cancer nursing, Vol.45(1), pp.E279-E290
- DOI
- 10.1097/NCC.0000000000000915
- PMID
- 33577204
- PMCID
- PMC8357857
- NLM abbreviation
- Cancer Nurs
- ISSN
- 0162-220X
- eISSN
- 1538-9804
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 12
- Grant note
- Midwest Nursing Research Society New Investigator Grant 1P20NR018081-01 / NINR; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) Holden Comprehensive Cancer Center Diana Benz Seed Grant
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Nursing; Internal Medicine
- Record Identifier
- 9984359899002771
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