Journal article
The Influence of pH-Adjusted 2-Chloroprocaine on the Quality and Duration of Subsequent Epidural Bupivacaine Analgesia during Labor: A Randomized, Double-blind Study
Anesthesiology (Philadelphia), Vol.70(3), pp.437-441
03/1989
DOI: 10.1097/00000542-198903000-00013
PMID: 2538094
Abstract
A randomized, double-blind study was performed to determine whether pH-adjustment of 2-chloroprocaine hastens the onset of epidural analgesia, and improves the quality and duration of subsequent epidural bupivacaine analgesia during labor. One milliliter of either 8.4% sodium bicarbonate or normal saline was added to a 30-ml vial of 2% 2-chloroprocaine. At 0, 5, and 7 min, each patient received 2, 5, and 3 ml of 2-chloroprocaine, respectively. At 22 min, any patient who did not yet have satisfactory analgesia received an additional 5 ml of 2-chloroprocaine. At 35, and, again, at 36 min, each patient received 5 ml of 0.25% bupivacaine. The median onset of 2-chloroprocaine analgesia was slightly more rapid in the bicarbonate group than in the saline-control group (12 versus 14 min, P less than .05). Two of 31 women in the bicarbonate group, versus 10 of 31 women in the saline-control group, required an additional 5 ml of 2-chloroprocaine at 22 min to achieve satisfactory analgesia (P = .01). There was no significant difference between groups in median duration of subsequent bupivacaine analgesia (60 min in each group) or mean (+/- SD) dosage of bupivacaine during the first stage of labor (64 +/- 43 versus 72 +/- 57 mg). Also, there was no significant difference between groups in pain scores over time.(ABSTRACT TRUNCATED AT 250 WORDS)
Details
- Title: Subtitle
- The Influence of pH-Adjusted 2-Chloroprocaine on the Quality and Duration of Subsequent Epidural Bupivacaine Analgesia during Labor: A Randomized, Double-blind Study
- Creators
- David H ChestnutMarianne GeigerJames N BatesWon W Chol
- Resource Type
- Journal article
- Publication Details
- Anesthesiology (Philadelphia), Vol.70(3), pp.437-441
- DOI
- 10.1097/00000542-198903000-00013
- PMID
- 2538094
- ISSN
- 0003-3022
- eISSN
- 1528-1175
- Language
- English
- Date published
- 03/1989
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006320902771
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