Journal article
The International Childhood Cardiovascular Cohort (i3C) consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: Design and recruitment
Contemporary clinical trials, Vol.69, pp.55-64
06/2018
DOI: 10.1016/j.cct.2018.04.009
PMCID: PMC5964041
PMID: 29684544
Abstract
Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U.S.) and Australia and a national health database in Finland. Microsoft Access, REsearch Data Capture (REDCap) (U.S.), LimeSurvey (Australia), and Medidata™ Rave data systems are used to collect, transfer and organize data. Self-reported CV events are adjudicated via hospital and doctor-released medical records. After the first two study years, participants (N = 10,968) were more likely to be female (56% vs. 48%), non-Hispanic white (90% vs. 80%), and older (10.4 ± 3.8 years vs. 9.4 ± 3.3 years) at their initial childhood study visit than the currently non-recruited cohort members. Over 48% of cohort members seen during both adulthood and childhood have been found and recruited, to date, vs. 5% of those not seen since childhood. Self-reported prevalences were 0.7% Type 1 Diabetes, 7.5% Type 2 Diabetes, 33% hypertension, and 12.8% CV event. 32% of CV events were judged to be true. I3C Outcomes is uniquely able to establish evidence-based guidelines for child health care and to clarify relations to adult CV disease.
Details
- Title: Subtitle
- The International Childhood Cardiovascular Cohort (i3C) consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: Design and recruitment
- Creators
- Alan R. Sinaiko - University of MinnesotaDavid R. Jacobs - University of MinnesotaJessica G. Woo - Cincinnati Children's Hospital Medical CenterLydia Bazzano - Tulane UniversityTrudy Burns - University of IowaTian Hu - University of MinnesotaMarkus Juonala - University of TurkuRonald Prineas - Wake Forest UniversityOlli Raitakari - University of TurkuJulia Steinberger - University of MinnesotaElaine Urbina - Cincinnati Children's Hospital Medical CenterAlison Venn - University of TasmaniaCashell Jaquish - National Heart Lung and Blood InstituteTerry Dwyer - University of Oxford
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.69, pp.55-64
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cct.2018.04.009
- PMID
- 29684544
- PMCID
- PMC5964041
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: RO1HL121230; DOI: 10.13039/100000002, name: NIH; DOI: 10.13039/501100002341, name: Academy of Finland
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363586002771
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