Journal article
The Interphase Gap Effect in Cochlear Implant Users: Biological Basis, Parameter Selection, Analytical Methods, and Quantitative Scales
Journal of the Association for Research in Otolaryngology
03/16/2026
DOI: 10.1007/s10162-026-01041-3
PMID: 41840299
Abstract
PurposeThis study aimed (1) to determine the biological basis of the interphase gap (IPG) effect and (2) to identify the most informative parameters, analytical methods, and quantitative scales for evaluating the IPG effect in human cochlear implant (CI) users.MethodsThe IPG effect was quantified using multiple parameters, analytical methods, and quantitative scales (three combinations using linear or logarithmic scales for the input and output variables) across three pediatric CI groups with differing cochlear nerve (CN) anatomy: children with cochlear nerve deficiency (CND), GJB2 mutations, and idiopathic sensorineural hearing loss (SNHL). All participants in the GJB2 and idiopathic SNHL groups had normal-sized CNs (NSCNs) in the test ear. Neural synchrony, a property depending on neural health, was assessed using phase locking value (PLV) and compared between children with CND and those with GJB2 mutations.ResultsThe PLV did not differ significantly between the CND and GJB2 groups, nor did it correlate with the IPG effect in GJB2 cases, regardless of parameter, analytical method, or quantitative scale. In contrast, consistent group differences in IPG effects on stimulation level offset and maximum slope of the eCAP input/output function were observed across all analytical methods and quantitative scales. The sensitivity of other eCAP measures-threshold, maximum amplitude, and overall linear slope-to group differences varied by quantitative scale.ConclusionsThe IPG effect primarily reflects the number of active CN fibers rather than their health. Stimulation level offset and the IPG effect on maximum slope are robust indicators of CN fiber counts in CI users and are unaffected by the choice of quantitative scale.
Details
- Title: Subtitle
- The Interphase Gap Effect in Cochlear Implant Users: Biological Basis, Parameter Selection, Analytical Methods, and Quantitative Scales
- Creators
- Shuman He - The Ohio State UniversityZi Gao - The Ohio State UniversityJacob J. Oleson - University of IowaIan C. Bruce - McMaster University
- Resource Type
- Journal article
- Publication Details
- Journal of the Association for Research in Otolaryngology
- DOI
- 10.1007/s10162-026-01041-3
- PMID
- 41840299
- NLM abbreviation
- J Assoc Res Otolaryngol
- ISSN
- 1525-3961
- eISSN
- 1438-7573
- Publisher
- Springer Nature
- Number of pages
- 26
- Grant note
- RGPIN-2024-05888 / Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada (NSERC); CGIAR R01 DC017846; R01DC022051-01A1 / National Institute on Deafness and Other Communication Disorders; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Language
- English
- Electronic publication date
- 03/16/2026
- Academic Unit
- Biostatistics; Otolaryngology
- Record Identifier
- 9985147179402771
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