Journal article
The Intersection of Genome, Epigenome and Social Experience in Autism Spectrum Disorder: Exploring Modifiable Pathways for Intervention
Neurobiology of learning and memory, Vol.202, pp.107761-107761
04/28/2023
DOI: 10.1016/j.nlm.2023.107761
PMCID: PMC10330448
PMID: 37121464
Abstract
[Display omitted]
•There is evidence that both genes and environment contribute to symptoms in autism.•Early social experience may be related to DNA methylation patterns in autism.•DNA methylation in the OXTR gene may influence social and cognitive outcomes.•Autism genetic risk variants may control DNA methylation and developmental outcomes.
The number of children diagnosed with autism spectrum disorder (ASD) has increased substantially over the past two decades. Current research suggests that both genetic and environmental risk factors are involved in the etiology of ASD. The goal of this paper is to examine how one specific environmental factor, early social experience, may be correlated with DNA methylation (DNAm) changes in genes associated with ASD. We present an innovative model which proposes that polygenic risk and changes in DNAm due to social experience may both contribute to the symptoms of ASD. Previous research on genetic and environmental factors implicated in the etiology of ASD will be reviewed, with an emphasis on the oxytocin receptor gene, which may be epigenetically altered by early social experience, and which plays a crucial role in social and cognitive development. Identifying an environmental risk factor for ASD (e.g., social experience) that could be modified via early intervention and which results in epigenetic (DNAm) changes, could transform our understanding of this condition, facilitate earlier identification of ASD, and guide early intervention efforts.
Details
- Title: Subtitle
- The Intersection of Genome, Epigenome and Social Experience in Autism Spectrum Disorder: Exploring Modifiable Pathways for Intervention
- Creators
- Lane Strathearn - Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USAAllison Momany - University of IowaEmese Kovács - Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, 51 Newton Road 2-471 Bowen Science Building, Iowa City, Iowa 52241, USAWilliam Guiler - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, 356 Medical Research Center, Iowa City, Iowa 52242, USAChristine Ladd-Acosta - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.202, pp.107761-107761
- DOI
- 10.1016/j.nlm.2023.107761
- PMID
- 37121464
- PMCID
- PMC10330448
- NLM abbreviation
- Neurobiol Learn Mem
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100009633, name: Eunice Kennedy Shriver National Institute of Child Health and Human Development; DOI: 10.13039/100000002, name: National Institutes of Health, award: P50 HD103556
- Language
- English
- Date published
- 04/28/2023
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology; Neonatology
- Record Identifier
- 9984400759402771
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