Journal article
The Iowa Longitudinal Study of Recent Onset Psychosis: One-year follow-up of first episode patients
Schizophrenia research, Vol.23(1), pp.1-13
1997
DOI: 10.1016/S0920-9964(96)00078-3
PMID: 9050123
Abstract
The natural history of schizophrenia remains unclear. One strategy to further inform this area is to prospectively evaluate individuals early in the course of the disorder, both in terms of symptomatic and psychosocial/occupational functioning. Subjects were recruited into the study if they were in the midst of their first psychiatric hospitalization for a non-‘organic’ psychotic disorder. Subjects were extensively evaluated at index with semi-structured interviews including the Comprehensive Assessment of Symptoms and History (CASH), and followed at 6-month intervals. Data are presented on 35 subjects who were followed through 1 year. There was a significant improvement in overall symptomatology during index hospitalization, but this was accounted for primarily by improvement of positive symptoms, with negative symptoms remaining prominent. No further improvement was noted between discharge and 1-year follow-up in any of the symptom measures. Employment, interpersonal relationships, and sexual activity remained markedly impaired throughout the follow-up period. These data demonstrate that; (1) negative symptoms are prominent and stable early in the course of the disorder; (2) symptom severity at discharge from index hospitalization is predictive of symptom severity at 1 year; and (3) despite substantial overall symptomatic improvement during the first hospitalization, psychosocial and occupational functioning were found to be markedly impaired at 1-year follow-up.
Details
- Title: Subtitle
- The Iowa Longitudinal Study of Recent Onset Psychosis: One-year follow-up of first episode patients
- Creators
- Sanjay Gupta - Mental Health Clinical Research Center, The University of Iowa College of Medicine, Room 2911 JPP,200 Hawkins Drive, Iowa City, IA 52242-1057, USANancy C Andreasen - Mental Health Clinical Research Center, The University of Iowa College of Medicine, Room 2911 JPP,200 Hawkins Drive, Iowa City, IA 52242-1057, USAStephan Arndt - Mental Health Clinical Research Center, The University of Iowa College of Medicine, Room 2911 JPP,200 Hawkins Drive, Iowa City, IA 52242-1057, USAMichael Flaum - Department of Psychiatry, The University of Iowa College of Medicine, Room 2911 JPP, 200 Hawkins Drive,Iowa City, IA 52242-1057, USAWilliam C Hubbard - Mental Health Clinical Research Center, The University of Iowa College of Medicine, Room 2911 JPP,200 Hawkins Drive, Iowa City, IA 52242-1057, USASteven Ziebell - Mental Health Clinical Research Center, The University of Iowa College of Medicine, Room 2911 JPP,200 Hawkins Drive, Iowa City, IA 52242-1057, USA
- Resource Type
- Journal article
- Publication Details
- Schizophrenia research, Vol.23(1), pp.1-13
- DOI
- 10.1016/S0920-9964(96)00078-3
- PMID
- 9050123
- NLM abbreviation
- Schizophr Res
- ISSN
- 0920-9964
- eISSN
- 1573-2509
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1997
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984003415502771
Metrics
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