The Kety-Schmidt technique for quantitative perfusion and oxygen metabolism measurements in the MR imaging environment

J J Lee; W J Powers; C B Faulkner; P J Boyle; C P Derdeyn

doi:10.3174/ajnr.A3270

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The Kety-Schmidt technique for quantitative perfusion and oxygen metabolism measurements in the MR imaging environment

Journal article

Open access

Peer reviewed

The Kety-Schmidt technique for quantitative perfusion and oxygen metabolism measurements in the MR imaging environment

J J Lee, W J Powers, C B Faulkner, P J Boyle and C P Derdeyn

American journal of neuroradiology : AJNR, Vol.34(9), pp.E100-E102

09/2013

DOI: 10.3174/ajnr.A3270

PMCID: PMC3868472

PMID: 22997166

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https://doi.org/10.3174/ajnr.A3270View

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Abstract

The Kety-Schmidt technique provides quantitative measurement of whole-brain CBF. CBF is measured as the area between the arterial and venous washout curves of a diffusible tracer. Oxygen extraction and metabolism may be calculated from arterial and venous samples. In this report, we present a method for performing these measurements in an MR imaging environment. This technique could be useful for validation of MR imaging methods of hemodynamic and metabolic measurements in humans.

Algorithms

Reproducibility of Results

Brain - anatomy & histology

Humans

Image Interpretation, Computer-Assisted - methods

Macaca fascicularis

Male

Oximetry - methods

Nitrous Oxide - pharmacokinetics

Papio anubis

Oxygen Consumption - physiology

Oxygen - metabolism

Brain - metabolism

Animals

Models, Biological

Computer Simulation

Sensitivity and Specificity

Female

Magnetic Resonance Angiography - methods

Details

Title: Subtitle: The Kety-Schmidt technique for quantitative perfusion and oxygen metabolism measurements in the MR imaging environment
Creators: J J Lee - Mallinckrodt Institute of Radiology
W J Powers
C B Faulkner
P J Boyle
C P Derdeyn
Resource Type: Journal article
Publication Details: American journal of neuroradiology : AJNR, Vol.34(9), pp.E100-E102
DOI: 10.3174/ajnr.A3270
PMID: 22997166
PMCID: PMC3868472
NLM abbreviation: AJNR Am J Neuroradiol
ISSN: 0195-6108
eISSN: 1936-959X
Publisher: United States
Grant note: R01 NS039864 / NINDS NIH HHS P01 NS35966 / NINDS NIH HHS
Language: English
Date published: 09/2013
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020613102771

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3 Times Cited - Web of Science