Journal article
The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations
Contemporary clinical trials, Vol.74, pp.76-87
11/2018
DOI: 10.1016/j.cct.2018.09.010
PMCID: PMC6203612
PMID: 30248454
Abstract
The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are associated with abnormal lower urinary tract symptoms (LUTS) in patients with overactive bladder syndrome (OAB). The NIST Study tests the hypotheses that patients with urinary urgency will demonstrate: (1) abnormal functional and structural connectivity of brain regions involved in urinary sensation on magnetic resonance imaging (MRI), and (2) hypersensitivity to painful (pressure) and non-painful (auditory) sensory stimuli on quantitative sensory testing (QST), compared to controls. Male and female adults (18 years or older) who present at one of the six participating LURN clinical centers for clinical care of their LUTS, with symptoms of urinary urgency with or without urgency urinary incontinence, are eligible to participate. The NIST Study is the largest MRI and QST study of its kind, yielding a neuroimaging and sensory testing dataset unprecedented in OAB research. Advanced multi-modal techniques are used to understand brain functional and structural connectivity, including gray matter volume, and sensory function. Unlike previous MRI studies which involved invasive catheterization and repeated cycles of non-physiologic bladder filling and emptying via a catheter, we use a water ingestion protocol to mimic more physiological bladder filling through natural diuresis. Furthermore, these data will be used in concert with other phenotyping data to improve our understanding of clinically meaningful subtypes of patients with LUTS in order to improve patient care and management outcomes.
Details
- Title: Subtitle
- The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations
- Creators
- H. Henry Lai - Departments of Surgery (Urology) and Anesthesiology, Washington University in St. Louis, St. Louis, MO, United StatesBruce Naliboff - Departments of Medicine and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United StatesAlice B Liu - Department of Urology, University of Washington, Seattle, WA, United StatesCindy L Amundsen - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, United StatesJoshua S Shimony - Mallinckrodt Institute of Radiology, Washington University in St Louis, St. Louis, MO, United StatesVincent A Magnotta - Department of Radiology, University of Iowa, Iowa City, IA, United StatesJoseph J Shaffer - Department of Radiology, University of Iowa, Iowa City, IA, United StatesRobin L Gilliam - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, United StatesJonathan B Wiseman - Arbor Research Collaborative for Health, Ann Arbor, MI, United StatesMargaret E Helmuth - Arbor Research Collaborative for Health, Ann Arbor, MI, United StatesVictor P Andreev - Arbor Research Collaborative for Health, Ann Arbor, MI, United StatesZiya Kirkali - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United StatesSteven E Harte - Departments of Anesthesiology and Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, United States
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.74, pp.76-87
- DOI
- 10.1016/j.cct.2018.09.010
- PMID
- 30248454
- PMCID
- PMC6203612
- NLM abbreviation
- Contemp Clin Trials
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, DK097776, DK099879; DOI: 10.13039/100007059, name: Northwestern University; name: National Institutes of Health’s National Center for Advancing Translational Sciences, award: UL1TR001422; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: K23-DK110417; DOI: 10.13039/100006510, name: Duke University, award: DK097780; DOI: 10.13039/100008893, name: University of Iowa, award: DK097772; DOI: 10.13039/100007059, name: Northwestern University, award: DK097779; DOI: 10.13039/100012797, name: NorthShore University HealthSystem; DOI: 10.13039/100007270, name: University of Michigan, award: DK099932; DOI: 10.13039/100007812, name: University of Washington, award: DK100011; DOI: 10.13039/100007268, name: Washington University in St. Louis, award: DK100017; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases; name: Arbor Research Collaborative for Health, Data Coordinating Center, award: DK097776, DK099879
- Language
- English
- Date published
- 11/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Urology
- Record Identifier
- 9984051521102771
Metrics
11 Record Views