Journal article
The Landmark JDRF Continuous Glucose Monitoring Randomized Trials: a Look Back at the Accumulated Evidence
Journal of cardiovascular translational research, Vol.5(4), pp.380-387
08/01/2012
DOI: 10.1007/s12265-012-9364-9
PMID: 22538483
Abstract
Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c > 7.0 %. The secondary study evaluated 129 patients with A1c < 7.0 %. In the primary study, CGM resulted in improvements in A1c at 6 m in subjects > 25 years, but not those < 25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.
Details
- Title: Subtitle
- The Landmark JDRF Continuous Glucose Monitoring Randomized Trials: a Look Back at the Accumulated Evidence
- Creators
- Katrina J. Ruedy - Jaeb Center for Health ResearchWilliam V. Tamborlane - Yale UniversityJuvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
- Contributors
- Michael Tansey (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular translational research, Vol.5(4), pp.380-387
- Publisher
- Springer Nature
- DOI
- 10.1007/s12265-012-9364-9
- PMID
- 22538483
- ISSN
- 1937-5387
- eISSN
- 1937-5395
- Number of pages
- 8
- Language
- English
- Date published
- 08/01/2012
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984353846902771
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