Journal article
The Landmark Series: Neuroendocrine Tumor Liver Metastases
Annals of surgical oncology, Vol.27(9), pp.3270-3280
07/06/2020
DOI: 10.1245/s10434-020-08787-x
PMCID: PMC7415723
PMID: 32632880
Abstract
Background: Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver. Methods: In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as several randomized control trials which have investigated strategies for systemic control of metastatic disease. Results: Liver-directed surgical approaches and locally ablative procedures are recommended for patients with limited, resectable, and in some cases, nonresectable tumor burden. Angiographic liver-directed techniques, such as transarterial embolization, chemoembolization, and radioembolization, offer another approach for management in patients with liver-predominant disease. Peptide receptor radionuclide therapy is a promising therapy for patients with hepatic and/or extrahepatic metastases. Various systemic medical therapies are also available as adjunct or definitive therapy for patients with metastatic disease. Conclusions: This article reviews current data regarding management of neuroendocrine liver metastases and highlights areas for future study.
Details
- Title: Subtitle
- The Landmark Series: Neuroendocrine Tumor Liver Metastases
- Creators
- Alexandra Gangi - Cedars-Sinai Medical CenterJames R. Howe - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of surgical oncology, Vol.27(9), pp.3270-3280
- DOI
- 10.1245/s10434-020-08787-x
- PMID
- 32632880
- PMCID
- PMC7415723
- NLM abbreviation
- Ann Surg Oncol
- ISSN
- 1068-9265
- eISSN
- 1534-4681
- Grant note
- name: SPORE in Neuroendocrine Tumors, award: P50 CA174521-01
- Language
- English
- Date published
- 07/06/2020
- Academic Unit
- Surgery
- Record Identifier
- 9984322953402771
Metrics
10 Record Views