Journal article
The Latest Evidence on Bempedoic Acid: Meta-Analysis of Safety and Efffiicacy in High Cardiovascular Risk Patients with Hypercholesterolemia
Journal of community hospital internal medicine perspectives, Vol.14(2), 3
03/04/2024
DOI: 10.55729/2000-9666.1305
PMCID: PMC11221435
PMID: 38966502
Abstract
Background: Bempedoic Acid (BA) is a novel drug that has a potential to serve as an alternative to statins to decrease lipid levels and improve cardiovascular disease (CVD) outcomes, particularly for statin-intolerant individuals. However, insufficient statistical power has limited our understanding of the efficacy and safety of BA. This meta-analysis utilizes the latest data to improve our knowledge of BA's effects on lipids and CVD with increased statistical power. Methods: MEDLINE, Embase, Cochrane Central, Clinicaltrials.gov, abstracts of national and international conferences, and reference lists of studies were searched for relevant studies. Rayyan was used to screen the search results, and Revman 5.3 was used for the meta-analysis and sensitivity analysis. Results: Our final analysis included seven randomized control trials (RCTs) with 17,782 participants, 53.6 % in the BA group (n = 9535) and 46.4 % in the placebo group (n = 8247). BA significantly decreased major adverse cardiovascular events (MACE) (OR: 0.86; 95 % CI 0.78-0.95; p = 0.03), non-fatal myocardial infarction (OR 0.72; 95 % CI 0.61-0.85; p = 0.0001), and new onset/worsening diabetes (OR:0.55; 95 % CI 0.30-0.98, p = 0.04), while reducing low-density lipoprotein cholesterol (LDL-C) levels by 22.5 % (MD: -22.53 %; 95 % CI -25.54 to -19.52, p < 0.00001). Conclusion: The findings of this meta-analysis suggest that BA is a promising and effective alternative to statin therapy, particularly for statin-intolerant and high CVD-risk patients. However, further studies with diverse populations are needed to quantify the long-term efficacy and safety endpoints.
Details
- Title: Subtitle
- The Latest Evidence on Bempedoic Acid: Meta-Analysis of Safety and Efffiicacy in High Cardiovascular Risk Patients with Hypercholesterolemia
- Creators
- Muhammad A. Afzal - St. Joseph’s University Medical CenterNoman Khalid - St. Joseph’s University Medical CenterMuhammad Abdullah - Shaikh Zayed Postgraduate Medical InstituteAta U. Haiy - King Edward Medical UniversityMubariz A. Hassan - Howard University HospitalHania Sana - King Edward Medical UniversitySherif Elkattawy - St. Joseph’s University Medical CenterAhmad A. Malik - King Abdulaziz UniversityPatrick Michael - St. Joseph’s University Medical CenterRahul Vasudev - St. Joseph’s University Medical CenterFayez Shamoon - St. Joseph’s University Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of community hospital internal medicine perspectives, Vol.14(2), 3
- DOI
- 10.55729/2000-9666.1305
- PMID
- 38966502
- PMCID
- PMC11221435
- NLM abbreviation
- J Community Hosp Intern Med Perspect
- ISSN
- 2000-9666
- eISSN
- 2000-9666
- Publisher
- DIGITAL COMMONS BEPRESS
- Number of pages
- 13
- Language
- English
- Date published
- 03/04/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984920932002771
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