The Lazaroid U74006F, a 21-Aminosteroid Inhibitor of Lipid Peroxidation, Attenuates Myocardial Injury from Ischemia and Reperfusion

Frank Carrea; Edward Lesnefsky; David Kaiser; Lawrence Horwitz

doi:10.1097/00005344-199208000-00008

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The Lazaroid U74006F, a 21-Aminosteroid Inhibitor of Lipid Peroxidation, Attenuates Myocardial Injury from Ischemia and Reperfusion

Journal article

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The Lazaroid U74006F, a 21-Aminosteroid Inhibitor of Lipid Peroxidation, Attenuates Myocardial Injury from Ischemia and Reperfusion

Frank Carrea, Edward Lesnefsky, David Kaiser and Lawrence Horwitz

Journal of cardiovascular pharmacology, Vol.20(2), pp.230-235

08/1992

DOI: 10.1097/00005344-199208000-00008

PMID: 1381014

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Abstract

SUMMARYU74006F, a novel new 21-aminosteroid inhibitor of lipid peroxidation, has been effective in preventing free-radical-mediated injury in central nervous system models. To assess its ability to diminish myocardial injury due to ischemia and reperfusion, U74006F (n = 11) or its vehicle (n = 11) were administered intravenously to New Zealand white rabbits. After allowing for distribution, the hearts were excised and exposed to 30 min of stop-flow ischemia and 30 min of reperfusion on a nonrecirculating Langendorf apparatus. There was diminished creatine phosphokinase release; improved peak positive dP/dt, developed pressure, and peak negative dP/dt; and diminished diastolic pressure in the group treated with U74006F. Thus, pretreatment with U74006F diminished myocardial injury and enhanced systolic and diastolic functional recovery, probably by protecting the lipid component of cell membranes from peroxidation by reactive oxygen metabolites.

Details

Title: Subtitle: The Lazaroid U74006F, a 21-Aminosteroid Inhibitor of Lipid Peroxidation, Attenuates Myocardial Injury from Ischemia and Reperfusion
Creators: Frank Carrea - University of Colorado Health
Edward Lesnefsky - University of Colorado Health
David Kaiser - University of Colorado Health
Lawrence Horwitz - University of Colorado Health
Resource Type: Journal article
Publication Details: Journal of cardiovascular pharmacology, Vol.20(2), pp.230-235
DOI: 10.1097/00005344-199208000-00008
PMID: 1381014
NLM abbreviation: J Cardiovasc Pharmacol
ISSN: 0160-2446
eISSN: 1533-4023
Publisher: Lippincott-Raven Publishers
Language: English
Date published: 08/1992
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984656533802771

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