Journal article
The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei
Neuron (Cambridge, Mass.), Vol.104(5), pp.849-855.e3
12/04/2019
DOI: 10.1016/j.neuron.2019.09.002
PMID: 31653463
Abstract
Cognitive activity emerges from large-scale neuronal dynamics that are constrained to a low-dimensional manifold. How this low-dimensional manifold scales with cognitive complexity, and which brain regions regulate this process, are not well understood. We addressed this issue by analyzing sub-second high-field fMRI data acquired during performance of a task that systematically varied the complexity of cognitive reasoning. We show that task performance reconfigures the low-dimensional manifold and that deviations from these patterns relate to performance errors. We further demonstrate that individual differences in thalamic activity relate to reconfigurations of the low-dimensional architecture during task engagement.
•Cognitive complexity causes alterations in the low-dimensional whole-brain dynamics•Deviations from the manifold dissociate correct from incorrect performance•Low-dimensional trajectories relate to activity in medial thalamic nuclei
Shine et al. demonstrate that cognitive complexity reconfigures the low-dimensional state space of the human brain. The low-dimensional trajectories of whole-brain activity dissociate correct and error trials and relate to activity within the medial and posterior thalamic nuclei.
Details
- Title: Subtitle
- The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei
- Creators
- James M Shine - The University of Sydney, Sydney, NSW 2050, AustraliaLuke J Hearne - Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USAMichael Breakspear - Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaKai Hwang - Department of Psychological and Brain Sciences and The Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA 52242, USAEli J Müller - The University of Sydney, Sydney, NSW 2050, AustraliaOlaf Sporns - Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USARussell A Poldrack - Department of Psychology, Stanford University, Stanford, CA 94305, USAJason B Mattingley - Queensland Brain Institute, The University of Queensland, St. Lucia, QLD 4072, AustraliaLuca Cocchi - QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.104(5), pp.849-855.e3
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuron.2019.09.002
- PMID
- 31653463
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Grant note
- name: University of Sydney Robinson; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1156536, 1099082, 1138711, 1118153; DOI: 10.13039/100000002, name: National Institutes of Health, award: RO1-AT009036; DOI: 10.13039/100007615, name: Australian Research Council, award: SR120300015, CE140100007, FL110100103
- Language
- English
- Date published
- 12/04/2019
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070550302771
Metrics
15 Record Views