The Low Prevalence and High Cost of Routine Antiphospholipid Antibody Testing in Patients with Recurrent Pregnancy Loss

Renee G Cafun; Anna Merrill; Sharathkumar M Bhagavathi; Karen M Summers; Brittany A Bettendorf; Bradley J Van Voorhis

doi:10.1016/j.fertnstert.2023.03.026

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The Low Prevalence and High Cost of Routine Antiphospholipid Antibody Testing in Patients with Recurrent Pregnancy Loss

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The Low Prevalence and High Cost of Routine Antiphospholipid Antibody Testing in Patients with Recurrent Pregnancy Loss

Renee G Cafun, Anna Merrill, Sharathkumar M Bhagavathi, Karen M Summers, Brittany A Bettendorf and Bradley J Van Voorhis

Fertility and sterility, Vol.119(6), pp.1078-1080

06/2023

DOI: 10.1016/j.fertnstert.2023.03.026

PMID: 36972747

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Abstract

Objective Testing for antiphospholipid antibodies (aPLs) is recommended and widely practiced for patients with recurrent pregnancy loss (RPL) based, in part, on a reported prevalence of antiphospholipid syndrome ranging from 8%–42% in patients experiencing multiple miscarriages (1). However, this prevalence may be inflated because these studies were performed before the implementation of new standardized guidelines for aPLs testing. Our primary objective was to evaluate the rate of confirmed aPL positivity in patients with RPL as currently defined by the American Society for Reproductive Medicine practice guidelines and according to the international recommendations for proper laboratory testing. Secondary objectives were to determine the costs associated with aPL testing and the clinical factors associated with aPL positivity among patients with RPL. The University of Iowa Institutional Review Board reviewed and approved the methods for this study (IRB# 202112378).

Details

Title: Subtitle: The Low Prevalence and High Cost of Routine Antiphospholipid Antibody Testing in Patients with Recurrent Pregnancy Loss
Creators: Renee G Cafun - University of Iowa Carver College of Medicine
Anna Merrill - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa
Sharathkumar M Bhagavathi - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa
Karen M Summers - University of Iowa
Brittany A Bettendorf - University of Iowa
Bradley J Van Voorhis - Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, Iowa. Electronic address: brad-van-voorhis@uiowa.edu
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.119(6), pp.1078-1080
DOI: 10.1016/j.fertnstert.2023.03.026
PMID: 36972747
NLM abbreviation: Fertil Steril
ISSN: 0015-0282
eISSN: 1556-5653
Language: English
Electronic publication date: 03/25/2023
Date published: 06/2023
Academic Unit: Pathology; Obstetrics and Gynecology; Injury Prevention Research Center; Immunology; Internal Medicine
Record Identifier: 9984381134802771

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