Journal article
The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
Science (American Association for the Advancement of Science), Vol.330(6010), pp.1551-1557
12/10/2010
DOI: 10.1126/science.1195271
PMCID: PMC3235490
PMID: 21051598
Abstract
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the
HLA-B
peptide binding groove, as well as an independent
HLA-C
effect, explain the SNP associations and reconcile both protective and risk
HLA
alleles. These results implicate the nature of the HLA–viral peptide interaction as the major factor modulating durable control of HIV infection.
Details
- Title: Subtitle
- The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
- Creators
- Florencia Pereyra - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USABisola O Ojikutu - MGH, Harvard Medical School, Boston, MA, USAMoti Ramgopal - Midway Immunology and Research Center, Fort Pierce, FL, USAJason Okulicz - Brooke Army Medical Center, San Antonio, TX, USASteven Santiago - CARE Resource, Miami, FL, USAMargret O Nelson - MGH, Harvard Medical School, Boston, MA, USAAlmas Rathod - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USACraig Nielsen - University of Colorado, Denver, Aurora, CO, USAJack T Stapleton - The University of Iowa, Iowa City, IA, USAOlakunle O Oladehin - MGH, Harvard Medical School, Boston, MA, USAMichael Rausch - Aerztezentrum Nollendorfplatz, Berlin, GermanyEdward C Oldfield - Eastern Virginia Medical School, Norfolk, VA, USAWolfgang Schmidt - Aerzteforum Seestrasse, Berlin, GermanySusan A Olender - Columbia University Medical Center, New York, NY, USAJ Ravishankar - State University of New York Downstate Medical Center, Brooklyn, NY, USAMario Ostrowski - University of Toronto, Toronto, CanadaBenjamin T Davis - MGH, Harvard Medical School, Boston, MA, USAWilliam F Owen - CA Pacific Medical Center, San Francisco, CA, USAFrank S Rhame - Clinic 42, Minneapolis, MN, USAEunice Pae - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAConstance Shamuyarira Richards - King Edward Memorial Hospital, Paget, BermudaJeffrey Parsonnet - Dartmouth-Hitchcock Medical Center, Lebanon, NH, USAHanneke Schuitemaker - Academic Medical Center Amsterdam, Amsterdam, NetherlandsAndrew M Pavlatos - St. Joseph Hospital, Chicago, IL, USAPhilip M Sestak - St. Paul’s Hospital, Vancouver, CanadaAaron M Perlmutter - Aaron M. Perlmutter, M.D., Beverly Hills, CA, USAMichael N Pierce - All Med and Rehabilitation of New York, Bronx, NY, USADouglas D Richman - University of California San Diego, San Diego, CA, USADavid M Lee - Uptown Physicians Group, Dallas, TX, USAHeather Calderon Pujet - Boulder Community Hospital, Boulder, CO, USABerta Rodes - Fundacion para la Investigacion Biomedica del Hospital Carlos III, Madrid, SpainJonathan M Pincus - Codman Square Health Center, Dorchester, MA, USASheree Starrett - Rivington House and Village Care, New York, NY, USALeandro Pisani - CARE Resource, Miami, FL, USAMilagros Rodriguez - CARE Resource, Miami, FL, USALawrence Jay Price - Castro-Mission Health Center, San Francisco, CA, USAPeter Shalit - Swedish Medical Center, Seattle, WA, USALaurie Proia - Rush Medical College, Chicago, IL, USARichard C RoseRichard C Prokesch - Infectious Disease Associates, Sarasota, FL, USASupriya Gupta - Broad Institute of Harvard and MIT, Cambridge, MA, USAEric S Rosenberg - MGH, Harvard Medical School, Boston, MA, USAHans-Jurgen Stellbrink - Infektionsmedizinisches Centrum Hamburg, Hamburg, GermanyDaniel Rosenthal - Medical Consultants of South Florida, Coral Springs, FL, USAMarcia Sokol-Anderson - St. Louis University, St Louis, MO, USAPolly E Ross - Western North Carolina Community Health Services, Asheville, NC, USAAmalio Telenti - Institute of Microbiology, University of Lausanne, Lausanne, SwitzerlandDavid S Rubin - New York Hospital Medical Center of Queens, Flushing, NY, USAJames M Sosman - University of Wisconsin in Madison, Madison, WI, USAElease Rumbaugh - Kaiser Permanente, Portland, OR, USALuis Saenz - CARE Resource, Miami, FL, USAWilliam Shay - St. Vincent’s Hospital, New York, NY, USAWilliam Theisen - Department of Medicine, Division of Infectious Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAMichelle R Salvaggio - University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAF. Lisa Sterman - California Pacific Medical Center, San Francisco, CA, USAWilliam C Sanchez - Georgetown University Medical Center, Washington, DC, USAVeeraf M Sanjana - Village Care Health Center, New York, NY, USAPaul Stabile - William F. Ryan Community Health Center, New York, NY, USAIsabel Vecino - University of North Texas Health Science Center, Fort Worth, TX, USADaniel A Warner - Consultive Medicine, Daytona Beach, FL, USAVivian N Shirvani - Cedars-Sinai Medical Center, Los Angeles, CA, USAPaul I.W de Bakker - Broad Institute of Harvard and MIT, Cambridge, MA, USAFrancine Stein - Visiting Nurse Association of Central New Jersey, Community Health Center, Asbury Park, NJ, USAVilma M Vega - Infectious Disease Associates, Sarasota, FL, USAValerie E Stone - MGH, Harvard Medical School, Boston, MA, USAVanessa I Silebi - Mercy Hospital, Miami, FL, USABruce D Walker - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAWenoah Veikley - Southwest C.A.R.E. Center, Santa Fe, NM, USAJames M Sizemore - University of Tennessee, Chattanooga, TN, USADavid R Stone - Lemuel Shattuck Hospital, Boston, MA, USABarbara H Wade - Infectious Diseases Associates of Northwest Florida, Pensacola, FL, USAGiuseppe Tambussi - Fondazione San Raffaele Del Monte Tabor, Milan, ItalyCharles Walworth - Center for Special Immunology, Fountain Valley, CA, USAPaul J McLaren - Broad Institute of Harvard and MIT, Cambridge, MA, USAEllen M Tedaldi - Temple University School of Medicine, Philadelphia, PA, USAChingchai Wanidworanun - Private Practice of Chingchai Wanidworanun, M.D., Arlington, VA, USAPaul R Skolnik - Boston University Medical Center, Boston, MA, USAStephan Ripke - Broad Institute of Harvard and MIT, Cambridge, MA, USAMary Carrington - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USARandy A Taplitz - University of California San Diego, San Diego, CA, USADouglas J Ward - Dupont Circle Physician’s Group, Washington, DC, USASara L Pulit - Broad Institute of Harvard and MIT, Cambridge, MA, USAChanson J Brumme - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USACarl M Kadie - Microsoft Research, Redmond, WA, USARichard Torres - Yale University School of Medicine, Bridgeport, CT, USAJonathan M Carlson - Microsoft Research, Los Angeles, CA, USALorraine Tosiello - Jersey City Medical Center, Jersey City, NJ, USADavid Heckerman - Microsoft Research, Los Angeles, CA, USALeela Davies - Broad Institute of Harvard and MIT, Cambridge, MA, USACecile Tremblay - University of Montreal, Montreal, CanadaRobert R Graham - Genentech, South San Francisco, CA, USAAmy Camargo - Broad Institute of Harvard and MIT, Cambridge, MA, USAJamie M Moore - Broad Institute of Harvard and MIT, Cambridge, MA, USAMarc A Tribble - Baylor University Medical Center, Dallas, TX, USAPhuong D Trinh - Montgomery Infectious Disease Associates, Silver Spring, MD, USANicole Beattie - Broad Institute of Harvard and MIT, Cambridge, MA, USARobert M Plenge - Broad Institute of Harvard and MIT, Cambridge, MA, USASteven G Deeks - University of California San Francisco, San Francisco, CA, USAAndrew Crenshaw - Broad Institute of Harvard and MIT, Cambridge, MA, USAAlice Tsao - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USANoël P Burtt - Broad Institute of Harvard and MIT, Cambridge, MA, USACandace Guiducci - Broad Institute of Harvard and MIT, Cambridge, MA, USALauren Gianniny - Broad Institute of Harvard and MIT, Cambridge, MA, USAPeggy Ueda - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USANamrata Gupta - Broad Institute of Harvard and MIT, Cambridge, MA, USAXiaojiang Gao - Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, NCI-Frederick, Frederick, MD, USAGabriel Crawford - Broad Institute of Harvard and MIT, Cambridge, MA, USAAnthony Vaccaro - Northwestern University, Chicago, IL, USAYing Qi - Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, NCI-Frederick, Frederick, MD, USAYuko Yuki - Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, NCI-Frederick, Frederick, MD, USAJordan Sullivan - Broad Institute of Harvard and MIT, Cambridge, MA, USAAlicja Piechocka-Trocha - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAEmilia Valadas - Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Lisbon, PortugalThanes J Vanig - Spectrum Medical Group, Phoenix, AZ, USAEmily Cutrell - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAElena Gonzalez - Broad Institute of Harvard and MIT, Cambridge, MA, USARachel Rosenberg - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAKristin L Moss - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAPaul Lemay - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAJessica O’Leary - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USATodd Schaefer - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAPranshu Verma - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAIldiko Toth - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USABrian Block - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USABrett Baker - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAAlissa Rothchild - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAJeffrey Lian - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAJacqueline Proudfoot - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USADonna Marie L Alvino - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USASeanna Vine - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USARobert W Shafer - Stanford University, Palo Alto, CA, USAMarylyn M Addo - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USATodd M Allen - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USARoy M Gulick - Weill Medical College of Cornell University, New York, NY, USAMarcus Altfeld - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USACecilia M Shikuma - Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USAMatthew R Henn - Broad Institute of Harvard and MIT, Cambridge, MA, USARichard Haubrich - University of California San Diego, San Diego, CA, USASylvie Le Gall - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USASharon Riddler - University of Pittsburgh, Pittsburgh, PA, USAHendrik Streeck - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAPaul E Sax - Department of Medicine, Division of Infectious Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAEric S Daar - University of California Los Angeles, Los Angeles, CA, USADavid W Haas - Vanderbilt University School of Medicine, Nashville, TN, USADaniel R Kuritzkes - Department of Medicine, Division of Infectious Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAHeather J Ribaudo - Department of Biostatistics, Harvard School of Public Health, Boston, MA, USAGregory K Robbins - MGH, Harvard Medical School, Boston, MA, USABrian Agan - Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USAShanu Agarwal - Summa Health System, Akron, OH, USARichard L Ahern - MGH, Harvard Medical School, Boston, MA, USABrady L Allen - Uptown Physicians Group, Dallas, TX, USASherly Altidor - St. Luke’s Roosevelt Hospital, New York, NY, USAStephen J Brown - AIDS Research Alliance, Los Angeles, CA, USAEric L Altschuler - New Jersey Medical School, University Hospital, Newark, NJ, USAKatherine Brown - David Powell Community Health Center, Austin, TX, USASujata Ambardar - Infectious Disease Physicians, Annandale, VA, USASheldon T Brown - James J. Peters VA Medical Center, Bronx, NY, USAKathryn Anastos - Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USAJedidiah Burack - Sunrise Medical Group, Brooklyn, NY, USABen Anderson - St. Leonards Medical Centre, St. Leonards, AustraliaLarry M Bush - University of Miami-Miller School of Medicine, Lake Worth, FL, USAVirginia Cafaro - WellSpring Medical Group, San Francisco, CA, USAVal Anderson - Ysbyty Gwynedd Hospital, Gwynedd, UKUshan Andrady - Ysbyty Gwynedd Hospital, Gwynedd, UKOmobolaji Campbell - MGH, Harvard Medical School, Boston, MA, USADiana Antoniskis - Kaiser Permanente, Portland, OR, USAJohn Campbell - Moses Cone Health System, Greensboro, NC, USADavid Bangsberg - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USARobert H Carlson - HealthPartners Infectious Disease, St Paul, MN, USADaniel Barbaro - Tarrant County Infectious Disease Associates, Fort Worth, TX, USAJ. Kevin Carmichael - El Rio Special Immunology Associates, Tuscon, AZ, USAWilliam Barrie - Private Practice of William Barrie, Toronto, CanadaKathleen K Casey - Jersey Shore University Medical Center, Neptune, NJ, USAJ Bartczak - Rowan Tree Medical, Wilton Manors, FL, USAChris Cavacuiti - St. Michaels Hospital, Toronto, CanadaSimon Barton - Chelsea and Westminster Hospital, St. Stephen’s Centre, London, UKGregory Celestin - The Brooklyn Hospital Center, PATH Center, Brooklyn, NY, USASteven T Chambers - University of Otago, Christchurch, New ZealandPatricia Basden - Beaver Street Family Practice, Flagstaff, AZ, USANesli Basgoz - MGH, Harvard Medical School, Boston, MA, USANancy Chez - H.E.L.P./Project Samaritan, Bronx, NY, USASuzane Bazner - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USALisa M Chirch - David E. Rogers Center for HIV/AIDS Care, Southampton, NY, USAPaul J Cimoch - Center for Special Immunology, Fountain Valley, CA, USANicholaos C Bellos - Southwest Infectious Disease Associates, Dallas, TX, USAAnne M Benson - Beaver Street Family Practice, Flagstaff, AZ, USADaniel Cohen - Fenway HealthJudith Berger - St. Barnabas Hospital, Bronx, NY, USALillian E Cohn - 9th Street Internal Medicine Associates, Philadelphia, PA, USANicole F Bernard - Research Institute, McGill University Health Centre, Montreal General Hospital, Montreal, CanadaBrian Conway - University of British Columbia, Vancouver, CanadaAnnette M Bernard - Thacker, Thompson and Bernard, Atlanta, GA, USADavid A Cooper - National Centre in HIV Epidemiology and Clinical Research, Sydney, AustraliaChristopher Birch - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USABrian Cornelson - St. Michaels Hospital, Toronto, CanadaStanley J Bodner - Vanderbilt University School of Medicine, Hermitage, TN, USADavid T Cox - Metro Infectious Disease Consultants, Indianapolis, IN, USARobert K Bolan - LA Gay and Lesbian Center, Los Angeles, CA, USAMichael V Cristofano - John H. Stroger Hospital of Cook County, Chicago, IL, USAEmilie T Boudreaux - Louisiana State University Health Sciences Center, University Medical Center East Clinic, Lafayatte, LA, USAGeorge Cuchural - New England Quality Care Alliance, Braintree, MA, USAMeg Bradley - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAJulie L Czartoski - Fred Hutchinson Cancer Research Center, Seattle, WA, USAJames F Braun - Physicians’ Research Network, Callen-Lorde Community Health Center, New York, NY, USAJoseph M Dahman - Desert AIDS Project, Palm Springs, CA, USAJon E Brndjar - Brndjar Medical Associates, Allentown, PA, USAJennifer S Daly - University of Massachusetts Memorial Medical Center, Worcester, MA, USAKristine Davis - University of Iowa Hospitals and Clinics, Iowa City, IA, USASheila M Davod - MGH, Harvard Medical School, Boston, MA, USAEdwin DeJesus - Orlando Immunology Center, Orlando, FL, USACraig A Dietz - The Kansas City Free Health Clinic, Kansas City, MO, USAEleanor Dunham - David E. Rogers Center for HIV/AIDS Care, Southampton, NY, USAMichael E Dunn - Private Practice of Michael E. Dunn, M.D., Tampa, FL, USATodd B Ellerin - South Shore Hospital, Weymouth, MA, USAJoseph J Eron - University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJohn J.W Fangman - AIDS Resource Center of Wisconsin, Milwaukee, WI, USAClaire E Farel - Department of Medicine, Division of Infectious Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAHelen Ferlazzo - Visiting Nurse Association of Central New Jersey, Community Health Center, Asbury Park, NJ, USASarah Fidler - Imperial College, London, UKAnita Fleenor-Ford - Heartland Clinic, Paducah, KY, USARenee Frankel - Morristown Memorial Hospital, Morristown, NJ, USAKenneth A Freedberg - MGH, Harvard Medical School, Boston, MA, USANeel K French - Private Practice of Neel K. French, M.D., Chicago, IL, USAJonathan D Fuchs - San Francisco Department of Public Health, San Francisco, CA, USAJon D Fuller - Boston University Medical Center, Boston, MA, USAJonna Gaberman - Baystate Medical Center, Springfield, MA, USAJoel E Gallant - Johns Hopkins University School of Medicine, Baltimore, MD, USARajesh T Gandhi - MGH, Harvard Medical School, Boston, MA, USAEfrain Garcia - Private Practice of Efrain Garcia, M.D., Miami, FL, USADonald Garmon - The Rockefeller University, New York, NY, USAJoseph C Gathe - Private Practice of Joseph C. Gathe Jr., M.D., Houston, TX, USACyril R Gaultier - Tower Infectious Disease, Los Angeles, CA, USAWondwoosen Gebre - Nassau University Medical Center, East Meadow, NY, USAFrank D Gilman - Sharp Rees Stealy Medical Center, San Diego, CA, USAIan Gilson - Medical College of Wisconsin, Milwaukee, WI, USAPaul A Goepfert - University of Alabama, Birmingham, Birmingham, AL, USAMichael S Gottlieb - Synergy Hematology and Oncology, Los Angeles, CA, USAClaudia Goulston - University of Utah, Salt Lake City, UT, USARichard K Groger - South Dayton Acute Care Consultants, Dayton, OH, USAT. Douglas Gurley - T. Douglas Gurley, M.D., Atlanta, GA, USAStuart Haber - St. Vincent’s Hospital, New York, NY, USARobin Hardwicke - University of Texas Health Science Center, Houston, TX, USAW. David Hardy - University of California Los Angeles, Los Angeles, CA, USAP. Richard Harrigan - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, CanadaTrevor N Hawkins - Southwest C.A.R.E. Center, Santa Fe, NM, USASonya Heath - University of Alabama, Birmingham, Birmingham, AL, USAFrederick M Hecht - University of California San Francisco, San Francisco, CA, USAW. Keith Henry - Hennepin County Medical Center, Minneapolis, MN, USAMelissa Hladek - The Catholic University of America, School of Nursing, Washington, DC, USARobert P Hoffman - Mercy Medical Center, Springfield, MA, USAJames M Horton - CMC Myers Park Medical Center, Charlotte, NC, USARicky K Hsu - New York University Medical Center, New York, NY, USAGregory D Huhn - The Ruth M. Rothshon Care Center, Chicago, IL, USAPeter Hunt - University of California San Francisco, San Francisco, CA, USAMark J Hupert - Tarrant County Infectious Disease Associates, Fort Worth, TX, USAMark L Illeman - Feldman Medical Group, San Francisco, CA, USAHans Jaeger - HIV Research and Clinical Care Centre, Munich, GermanyRobert M Jellinger - Albany Medical College, Albany, NY, USAMina John - Murdoch University, Murdoch, AustraliaKristin L Johnson - MGH, Harvard Medical School, Boston, MA, USAHeather Johnson - Tarrant County Infectious Disease Associates, Fort Worth, TX, USAJennifer A Johnson - Brigham and Women's HospitalKay Johnson - University of Cincinnati, Cincinnati, OH, USAJennifer Joly - David E. Rogers Center for HIV/AIDS Care, Southampton, NY, USAWilbert C Jordan - OASIS Clinic, Los Angeles, CA, USACarol A Kauffman - VA Ann Arbor Healthcare System, Ann Arbor, MI, USAHomayoon Khanlou - AIDS Healthcare Foundation, Los Angeles, CA, USARobert K Killian - Capitol Hill Medical, Seattle, WA, USAArthur Y Kim - MGH, Harvard Medical School, Boston, MA, USADavid D Kim - Astor Medical Group, New York, NY, USAClifford A Kinder - The Kinder Medical Group, Miami, FL, USAJeffrey T Kirchner - Lancaster General Hospital, Lancaster, PA, USALaura Kogelman - Tufts Medical Center, Boston, MA, USAErna Milunka Kojic - Alpert Medical School of Brown University, Providence, RI, USAP. Todd Korthuis - Oregon Health and Science University, Portland, OR, USAWayne Kurisu - Sharp Rees Stealy Medical Center, San Diego, CA, USADouglas S Kwon - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAMelissa LaMar - The Rockefeller University, New York, NY, USAHarry Lampiris - University of California San Francisco, San Francisco, CA, USAMassimiliano Lanzafame - G.B. Rossi Hospital, Verona, ItalyMichael M Lederman - Case Western Reserve University, Cleveland, OH, USAJean M.L Lee - Fred Hutchinson Cancer Research Center, Seattle, WA, USAMarah J Lee - LifeWay, Fort Lauderdale, FL, USAEdward T.Y Lee - Saint Claire Medical Associate, Toronto, CanadaJanice Lemoine - Greater Lawrence Family Health Center, Lawrence, MA, USAJay A Levy - University of California San Francisco, San Francisco, CA, USAJosep M Llibre - Hospital Universitari Germans Trias i Pujol, Barcelona, SpainMichael A Liguori - New York University Medical Center, New York, NY, USASusan J Little - University of California San Diego, San Diego, CA, USAAnne Y Liu - Department of Medicine, Division of Infectious Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAAlvaro J Lopez - Infectious Disease Consultants, Tucker, GA, USAMono R Loutfy - University of Toronto, Toronto, CanadaDawn Loy - Infectious Disease Associates, Sarasota, FL, USADebbie Y Mohammed - New Jersey Medical School, University Hospital, Newark, NJ, USAAlan Man - Kaiser Permanente, Portland, OR, USAMichael K Mansour - MGH, Harvard Medical School, Boston, MA, USAVincent C Marconi - Emory University, School of Medicine, Atlanta, GA, USAMartin Markowitz - Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY, USARui Marques - Deruico Doencas Infecciosas, Porto, PortugalJeffrey N Martin - University of California San Francisco, San Francisco, CA, USAHarold L Martin - Park Nicollet Clinic, St. Louis, MN, USAKenneth Hugh Mayer - Fenway Community Health, Boston, MA, USAM. Juliana McElrath - Fred Hutchinson Cancer Research Center, Seattle, WA, USATheresa A McGhee - Absolute Care, Atlanta, GA, USABarbara H McGovern - Tufts Medical Center, Boston, MA, USAKatherine McGowan - Department of Medicine, Division of Infectious Disease, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USADawn McIntyre - Jersey Shore University Medical Center, Neptune, NJ, USAGavin X Mcleod - College of Physicians and Surgeons, Columbia University, New York, NY, USAPrema Menezes - University of North Carolina at Chapel Hill, Chapel Hill, NC, USAGreg Mesa - Highland Medical Associates, Hendersonville, NC, USACraig E Metroka - St. Luke’s Roosevelt Hospital, New York, NY, USADirk Meyer-Olson - Medizinische Hochschule, Abteilung Klinische Immunologie, Hannover, GermanyAndy O Miller - Hospital for Special Surgery, New York, NY, USAKate Montgomery - Family Practice Specialists,Phoenix,AZ,USAKaram C Mounzer - Philadelphia FIGHT, Philadelphia, PA, USADavid L Norene - Sutter Medical Group, Sacramento, CA, USAEllen H Nagami - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAIris Nagin - Lower East Side Service Center, New York, NY, USADavid H O’Connor - University of Wisconsin in Madison, Madison, WI, USARonald G Nahass - Infectious Diseases Care, Hillsborough, NJ, USADuncan Webster - Saint John Regional Hospital, Saint John, CanadaSteve Weis - University of North Texas Health Science Center, Fort Worth, TX, USADavid A Wheeler - Clinical Alliance for Research and Education-Infectious Diseases, Annandale, VA, USADavid J White - Hawthorn House, Birmingham Heartlands Hospital, Birmingham, UKEd Wilkins - North Manchester General Hospital, Manchester, UKAlan Winston - Imperial College, London, UKClifford G Wlodaver - Private Practice of Clifford Wlodaver, Midwest City, OK, USAAngelique van’t Wout - Academic Medical Center Amsterdam, Amsterdam, NetherlandsDavid P Wright - Central Texas Clinical Research, Austin, TX, USAOtto O Yang - University of California Los Angeles, Los Angeles, CA, USADavid L Yurdin - Primary Health Care, Des Moines, IA, USABrandon W Zabukovic - Memorial Neighborhood Health Center Central Clinic, South Bend, IN, USAKimon C Zachary - MGH, Harvard Medical School, Boston, MA, USABeth Zeeman - Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USAMeng Zhao - United Health Services Hospitals, Binghamton, NY, USAInternational HIV Controllers Study
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.330(6010), pp.1551-1557
- DOI
- 10.1126/science.1195271
- PMID
- 21051598
- PMCID
- PMC3235490
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Grant note
- U01 AI069495-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069484-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069477-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069428-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069511-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI077505-04 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069556-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069432-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID UL1 RR024975-05 || RR / National Center for Research Resources : NCRR U01 AI069484-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069465-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069495-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID K24 AI069994-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 MH071205-05 || MH / National Institute of Mental Health : NIMH U01 AI069424-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069472-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069511-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069432-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI034853-12 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069424-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069471-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069450-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069450-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069472-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069556-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069477-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI030914-17 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI032782-13 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI046370-04 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID UM1 AI068636-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069513-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069502-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID UL1 RR024975-04 || RR / National Center for Research Resources : NCRR U01 AI069471-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069419-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069532-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI028568-20 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P30 AI027763-19 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069467-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069423-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069452-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069434-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI046370-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069502-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI030914-16 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069513-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069467-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069501-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069428-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069474-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID P30 AI027763-20 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069465-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI087145-02 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 MH085520-01 || MH / National Institute of Mental Health : NIMH U01 AI069532-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069419-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069501-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069452-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069423-06 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI069474-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 12/10/2010
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984094648802771
Metrics
41 Record Views