Journal article
The Many Faces of Granulomatosis With Polyangiitis: A Review of the Head and Neck Imaging Manifestations
American journal of roentgenology (1976), Vol.205(6), pp.W619-W629
12/2015
DOI: 10.2214/AJR.14.13864
PMID: 26587951
Abstract
Wegener granulomatosis has recently been renamed as granulomatosis with polyangiitis (GPA). In this review, we examine the clinical criteria and pathologic and pathophysiologic mechanisms of GPA, with an emphasis on findings encountered in the realm of head and neck imaging. Particular attention is paid to generating an appropriate differential diagnosis, because many of the imaging features of GPA overlap with those of other diseases, most notably lymphoma and sarcoidosis. Recent therapeutic advancements have underscored the importance of the radiologist in suggesting the diagnosis early, resulting in earlier treatment and decreased patient morbidity. This is particularly true for the head and neck manifestations of GPA; although they are less common, they often herald a refractory disease course that requires aggressive immunosuppressive therapy. Knowledge of common and uncommon imaging findings enables the radiologist to diagnose GPA early enough to start treatment promptly and reduce patient morbidity.
Although there are no reliable pathognomonic imaging features for GPA, the present article attempts to identify patterns of disease that are suggestive of the disease. The diagnosis ultimately relies on a constellation of radiographic findings, laboratory values, and accurate clinical history.
Details
- Title: Subtitle
- The Many Faces of Granulomatosis With Polyangiitis: A Review of the Head and Neck Imaging Manifestations
- Creators
- Marius G Pakalniskis - 1 Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246Aaron D Berg - 1 Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246Bruno A Policeni - 1 Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246Lindell R Gentry - 2 Department of Radiology, University of Wisconsin Hospitals and Clinics, Madison, WIYutaka Sato - 1 Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246Toshio Moritani - 1 Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246Wendy R K Smoker - 1 Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246
- Resource Type
- Journal article
- Publication Details
- American journal of roentgenology (1976), Vol.205(6), pp.W619-W629
- Publisher
- United States
- DOI
- 10.2214/AJR.14.13864
- PMID
- 26587951
- ISSN
- 0361-803X
- eISSN
- 1546-3141
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Radiology; Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984051519302771
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