Journal article
The Mechanism of Active Chloride Secretion by Airway Epithelia
Chest, Vol.81(5), pp.1-1
05/1982
DOI: 10.1378/chest.81.5_Supplement.1S-a
Abstract
Several electrophysiologic events accompany stimulation of Cl secretion across canine tracheal epithelium and these are entirely consistent with the model proposed for Cl-secreting tissues by Frizzell, Field and Schultz. The primary event in cAMP-induced active Cl secretion is an increase in apical membrane Cl permeability that permits Cl to exit from cell to mucosal solution in the direction of its electrochemical potential difference. A secondary increase in basolateral membrane K permeability results in increased conductive ion flow across this barrier to match that across the apical membrane. Whether secretagogues directly augment Na-K pump activity and/or NaCl co-transport across the basolateral membrane is not certain at the present time, but the secondary increase in basolateral membrane K permeability which accompanies their action has two effects: first, it provides for increased diffusional K exit from the cell to match the increase in Na-K pump rate so that cell composition is not markedly affected by large changes in transepithelial transport rate. Second, the resulting repolarization of the cell contributes, in an essential fashion, to the driving force for Cl exit from the cell across the apical membrane.
Details
- Title: Subtitle
- The Mechanism of Active Chloride Secretion by Airway Epithelia
- Creators
- Raymond A Frizzell - The University of Texas at AustinMichael J Welsh - The University of Texas at AustinPhilip L Smith - The University of Texas at Austin
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.81(5), pp.1-1
- Publisher
- Elsevier Inc
- DOI
- 10.1378/chest.81.5_Supplement.1S-a
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Language
- English
- Date published
- 05/1982
- Academic Unit
- Molecular Physiology and Biophysics; Neurosurgery; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine; Neurology; Pulmonary, Critical Care, and Occupational Medicine
- Record Identifier
- 9984259441502771
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