Journal article
The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis
Circulation research, Vol.95(10), pp.957-970
11/12/2004
DOI: 10.1161/01.RES.0000148632.35500.d9
PMID: 15539639
Abstract
Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
Details
- Title: Subtitle
- The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis
- Creators
- Michael T. Crow - Albert Einstein College of MedicineKartik Mani - Albert Einstein College of MedicineYoung-Jae Nam - Johns Hopkins UniversityRichard N. Kitsis - Albert Einstein College of Medicine
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.95(10), pp.957-970
- DOI
- 10.1161/01.RES.0000148632.35500.d9
- PMID
- 15539639
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 11/12/2004
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695684202771
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