The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network: Design and implementation of the Symptom Patterns Study (SPS)

J Quentin Clemens; Jason J Kutch; Emeran A Mayer; Bruce D Naliboff; Larissa V Rodriguez; David J Klumpp; Anthony J Schaeffer; Karl J Kreder; Daniel J Clauw; Steven E Harte; Andrew D Schrepf; David A Williams; Gerald L Andriole; H Henry Lai; Dedra Buchwald; M Scott Lucia; Adrie van Bokhoven; Sean Mackey; Robert M Moldwin; Michel A Pontari; Alisa J Stephens-Shields; Chris Mullins; J Richard Landis

doi:10.1002/nau.24423

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The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network: Design and implementation of the Symptom Patterns Study (SPS)

Journal article

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The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network: Design and implementation of the Symptom Patterns Study (SPS)

J Quentin Clemens, Jason J Kutch, Emeran A Mayer, Bruce D Naliboff, Larissa V Rodriguez, David J Klumpp, Anthony J Schaeffer, Karl J Kreder, Daniel J Clauw, Steven E Harte, …

Neurourology and urodynamics, Vol.39(6), pp.1803-1814

08/2020

DOI: 10.1002/nau.24423

PMCID: PMC8025696

PMID: 32578257

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https://www.ncbi.nlm.nih.gov/pmc/articles/8025696View

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Abstract

The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network initiated a second observational cohort study-the Symptom Patterns Study (SPS)-to further investigate the underlying pathophysiology of Urologic Chronic Pelvic Pain Syndrome (UCPPS) and to discover factors associated with longitudinal symptom changes and responses to treatments. This multisite cohort study of males and females with UCPPS features a run-in period of four weekly web-based symptom assessments before a baseline visit, followed by quarterly assessments up to 36 months. Controls were also recruited and assessed at baseline and 6 months. Extensive clinical data assessing urological symptoms, nonurological pain, chronic overlapping pain syndromes, and psychosocial factors were collected. Diverse biospecimens for biomarker and microbiome studies, quantitative sensory testing (QST) data under multiple stimuli, and structural and functional neuroimaging scans were obtained under a standardized protocol. Recruitment was initiated (July 2015) and completed (February 2019) at six discovery sites. A total of 620 males and females with UCPPS and 73 Controls were enrolled, including 83 UCPPS participants who re-enrolled from the first MAPP Network cohort study (2009-2012). Baseline neuroimaging scans, QST measures, and biospecimens were obtained on 578 UCPPS participants. The longitudinal follow-up of the cohort is ongoing. This comprehensive characterization of a large UCPPS cohort with extended follow-up greatly expands upon earlier MAPP Network studies and provides unprecedented opportunities to increase our understanding of UCPPS pathophysiology, factors associated with symptom change, clinically relevant patient phenotypes, and novel targets for future interventions.

Biomarkers

Neuroimaging

Phenotype

Adult

Chronic Pain - diagnosis

Chronic Pain - physiopathology

Cohort Studies

Female

Humans

Longitudinal Studies

Male

Middle Aged

Pelvic Pain - diagnosis

Pelvic Pain - physiopathology

Details

Title: Subtitle: The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network: Design and implementation of the Symptom Patterns Study (SPS)
Creators: J Quentin Clemens - Michigan Medicine
Jason J Kutch - University of Southern California
Emeran A Mayer - University of California, Los Angeles
Bruce D Naliboff - University of California, Los Angeles
Larissa V Rodriguez - University of Southern California
David J Klumpp - Northwestern University
Anthony J Schaeffer - Northwestern University
Karl J Kreder - University of Iowa Hospitals and Clinics
Daniel J Clauw - University of Michigan
Steven E Harte - University of Michigan
Andrew D Schrepf - University of Michigan
David A Williams - University of Michigan
Gerald L Andriole - Washington University in St. Louis
H Henry Lai - Washington University in St. Louis
Dedra Buchwald - Washington State University
M Scott Lucia - University of Colorado Denver
Adrie van Bokhoven - University of Colorado Denver
Sean Mackey - Stanford University
Robert M Moldwin - Hofstra University
Michel A Pontari - Temple University Hospital
Alisa J Stephens-Shields - University of Pennsylvania
Chris Mullins - National Institute of Diabetes and Digestive and Kidney Diseases
J Richard Landis - University of Pennsylvania
Resource Type: Journal article
Publication Details: Neurourology and urodynamics, Vol.39(6), pp.1803-1814
DOI: 10.1002/nau.24423
PMID: 32578257
PMCID: PMC8025696
NLM abbreviation: Neurourol Urodyn
ISSN: 0733-2467
eISSN: 1520-6777
Grant note: U01 DK082342 / NIDDK NIH HHS U01 DK103260 / NIDDK NIH HHS U01 DK082315 / NIDDK NIH HHS U01 DK082344 / NIDDK NIH HHS U01 DK103227 / NIDDK NIH HHS U24 DK082333 / NIDDK NIH HHS U01 DK082325 / NIDDK NIH HHS U01 DK103271 / NIDDK NIH HHS U01 DK082345 / NIDDK NIH HHS U01 DK082333 / NIDDK NIH HHS U24 DK082316 / NIDDK NIH HHS U01 DK082370 / NIDDK NIH HHS U01 DK082316 / NIDDK NIH HHS
Language: English
Date published: 08/2020
Academic Unit: Obstetrics and Gynecology; Urology
Record Identifier: 9984383916202771

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