Journal article
The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity
Neurobiology of learning and memory, Vol.105, pp.151-158
10/2013
DOI: 10.1016/j.nlm.2013.06.020
PMCID: PMC3790460
PMID: 23835142
Abstract
•NR4A transcription factor function is necessary for transcription-dependent Schaffer collateral long-term potentiation.•LTP enhancement by HDAC inhibitor treatment is blocked by expression of dominant-negative Nr4a transgene.•Basal properties of synaptic function are unaffected by loss of NR4A transcription factor activity.
Memory consolidation and long-term potentiation require activity-dependent gene transcription, coordinated by an array of transcription factors. Many members of the nuclear receptor superfamily of transcription factors are expressed in the hippocampus immediately after learning, including the Nr4a family of orphan receptors. These activity-dependent transcription factors are critical for hippocampus-dependent contextual fear and object recognition memory, but their role in hippocampal synaptic function is unknown. In this study, we hypothesized that Nr4a transcription factor function is also necessary for hippocampal long-term potentiation. We used a strain of mice expressing a dominant-negative Nr4a transgene. Hippocampal slices from Nr4aDN mutant mice exhibited impairments in transcription-dependent long-term potentiation and were not sensitive to LTP enhancement by the HDAC inhibitor TSA. These results demonstrate that NR4A transcription factor function mediates mechanisms of synaptic plasticity in the hippocampus.
Details
- Title: Subtitle
- The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity
- Creators
- Morgan S Bridi - Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, United StatesTed Abel - University of Pennsylvania, Department of Biology, 10-133 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, United States
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.105, pp.151-158
- DOI
- 10.1016/j.nlm.2013.06.020
- PMID
- 23835142
- PMCID
- PMC3790460
- NLM abbreviation
- Neurobiol Learn Mem
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Publisher
- Elsevier Inc
- Grant note
- name: NIH, award: R01-MH087463
- Language
- English
- Date published
- 10/2013
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065821602771
Metrics
23 Record Views