The National Cancer Data Base report on squamous cell carcinoma of the base of tongue

Weining Zhen; Lucy H Karnell; Henry T Hoffman; Gerry F Funk; John M Buatti; Herman R Menck

doi:10.1002/hed.20064

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The National Cancer Data Base report on squamous cell carcinoma of the base of tongue

Journal article

Peer reviewed

The National Cancer Data Base report on squamous cell carcinoma of the base of tongue

Weining Zhen, Lucy H Karnell, Henry T Hoffman, Gerry F Funk, John M Buatti and Herman R Menck

Head & neck, Vol.26(8), pp.660-674

08/2004

DOI: 10.1002/hed.20064

PMID: 15287033

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Abstract

This study provides the largest contemporary overview of presentation, care, and outcome for base of tongue squamous cell carcinoma (SCC). We extracted 16,188 cases from the National Cancer Data Base (NCDB). Chi-square analyses were performed on selected cross-tabulations. Observed and disease-specific survival were used to analyze outcome. Three-quarters had advanced-stage (III-IV) disease. Radiation therapy alone (24.5%) and combined with surgery (26.9%) were the most common treatments. Five-year observed and disease-specific survival rates were 27.8% and 40.3%, respectively. Poorer survival was significantly associated with older age, low income, and advanced-stage disease. For early-stage disease, surgery with or without irradiation had higher survival than irradiation alone. For advanced-stage disease, surgery with irradiation had the highest survival. Survival rates were low for base of tongue SCC, with most deaths occurring within the first 2 years. Income, stage, and age were significant prognostic factors. In this nonrandomized series, surgery with radiation therapy offered patients with advanced-stage disease the best survival.

Multivariate Analysis

United States - epidemiology

Tongue Neoplasms - diagnosis

Age Factors

Carcinoma, Squamous Cell - epidemiology

Tongue Neoplasms - therapy

Humans

Middle Aged

Carcinoma, Squamous Cell - therapy

Male

Treatment Outcome

Socioeconomic Factors

Carcinoma, Squamous Cell - diagnosis

Survival Analysis

Aged, 80 and over

Adult

Female

Aged

Retrospective Studies

Tongue Neoplasms - epidemiology

Neoplasm Staging - statistics & numerical data

Databases, Factual

Details

Title: Subtitle: The National Cancer Data Base report on squamous cell carcinoma of the base of tongue
Creators: Weining Zhen - Department of Radiation Oncology and Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, 987521 Nebraska Medical Center, Omaha, Nebraska 68198-7521, USA
Lucy H Karnell
Henry T Hoffman
Gerry F Funk
John M Buatti
Herman R Menck
Resource Type: Journal article
Publication Details: Head & neck, Vol.26(8), pp.660-674
Publisher: United States
DOI: 10.1002/hed.20064
PMID: 15287033
ISSN: 1043-3074
eISSN: 1097-0347
Language: English
Date published: 08/2004
Academic Unit: Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984006450702771

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82 Times Cited - Web of Science