Journal article
The Neural Correlates of Implicit Sequence Learning in Schizophrenia
Neuropsychology, Vol.21(6), pp.761-777
11/2007
DOI: 10.1037/0894-4105.21.6.761
PMCID: PMC2799042
PMID: 17983290
Abstract
Twenty-seven schizophrenia spectrum patients and 25 healthy controls performed a probabilistic version of the serial reaction time task (SRT) that included sequence trials embedded within random trials. Patients showed diminished, yet measurable, sequence learning. Postexperimental analyses revealed that a group of patients performed above chance when generating short spans of the sequence. This high-generation group showed SRT learning that was similar in magnitude to that of controls. Their learning was evident from the very 1st block; however, unlike controls, learning did not develop further with continued testing. A subset of 12 patients and 11 controls performed the SRT in conjunction with positron emission tomography. High-generation performance, which corresponded to SRT learning in patients, correlated to activity in the premotor cortex and parahippocampus. These areas have been associated with stimulus-driven visuospatial processing. Taken together, these results suggest that a subset of patients who showed moderate success on the SRT used an explicit stimulus-driven strategy to process the sequential stimuli. This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern.
Details
- Title: Subtitle
- The Neural Correlates of Implicit Sequence Learning in Schizophrenia
- Creators
- Cherie L Marvel - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of IowaBeth M Turner - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of IowaDaniel S O’Leary - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of IowaHans J Johnson - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of IowaRonald K Pierson - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of IowaLaura L Boles Ponto - Department of Radiology/Positron Emission Tomography (PET) Center, Roy J. and Lucille A. Carver College of Medicine, University of IowaNancy C Andreasen - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Neuropsychology, Vol.21(6), pp.761-777
- DOI
- 10.1037/0894-4105.21.6.761
- PMID
- 17983290
- PMCID
- PMC2799042
- NLM abbreviation
- Neuropsychology
- ISSN
- 0894-4105
- eISSN
- 1931-1559
- Grant note
- DOI: 10.13039/100012138, name: Nellie Ball Research Trust, award: T32 MH19113; T32 CA82106; R01 MH60990
- Language
- English
- Date published
- 11/2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Psychiatry; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984003442102771
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