Journal article
The Neuroanatomy of Speech Processing: A Large-scale Lesion Study
Journal of cognitive neuroscience, Vol.34(8), pp.1355-1375
07/01/2022
DOI: 10.1162/jocn_a_01876
PMCID: PMC9274306
PMID: 35640102
Abstract
The neural basis of language has been studied for centuries, yet the networks critically involved in simply identifying or understanding a spoken word remain elusive. Several functional–anatomical models of critical neural substrates of receptive speech have been proposed, including (1) auditory-related regions in the left mid-posterior superior temporal lobe, (2) motor-related regions in the left frontal lobe (in normal and/or noisy conditions), (3) the left anterior superior temporal lobe, or (4) bilateral mid-posterior superior temporal areas. One difficulty in comparing these models is that they often focus on different aspects of the sound-to-meaning pathway and are supported by different types of stimuli and tasks. Two auditory tasks that are typically used in separate studies—syllable discrimination and word comprehension—often yield different conclusions. We assessed syllable discrimination (words and nonwords) and word comprehension (clear speech and with a noise masker) in 158 individuals with focal brain damage: left (
= 113) or right (
= 19) hemisphere stroke, left (
= 18) or right (
= 8) anterior temporal lobectomy, and 26 neurologically intact controls. Discrimination and comprehension tasks are doubly dissociable both behaviorally and neurologically. In support of a bilateral model, clear speech comprehension was near ceiling in 95% of left stroke cases and right temporal damage impaired syllable discrimination. Lesion-symptom mapping analyses for the syllable discrimination and noisy word comprehension tasks each implicated most of the left superior temporal gyrus. Comprehension but not discrimination tasks also implicated the left posterior middle temporal gyrus, whereas discrimination but not comprehension tasks also implicated more dorsal sensorimotor regions in posterior perisylvian cortex.
Details
- Title: Subtitle
- The Neuroanatomy of Speech Processing: A Large-scale Lesion Study
- Creators
- Corianne Rogalsky - Arizona State UniversityAlexandra Basilakos - University of South CarolinaChris Rorden - University of South CarolinaSara Pillay - Medical College of WisconsinArianna N. LaCroix - Arizona State UniversityLynsey Keator - University of South CarolinaSoren Mickelsen - Arizona State UniversitySteven W. Anderson - University of IowaTracy Love - San Diego State UniversityJulius Fridriksson - University of South CarolinaJeffrey Binder - Medical College of WisconsinGregory Hickok - University of California, Irvine
- Resource Type
- Journal article
- Publication Details
- Journal of cognitive neuroscience, Vol.34(8), pp.1355-1375
- Publisher
- MIT Press
- DOI
- 10.1162/jocn_a_01876
- PMID
- 35640102
- PMCID
- PMC9274306
- ISSN
- 0898-929X
- eISSN
- 1530-8898
- Number of pages
- 21
- Grant note
- T32 DC0014435 / National Institute on Deafness and Other Communication Disorders R01 DC009659 / National Institute on Deafness and Other Communication Disorders
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Neurology
- Record Identifier
- 9984303011602771
Metrics
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